What Makes Us Fat? The Genetics of Appetite | Giles Yeo
💬 Dr. Giles Yeo is a geneticist and obesity researcher at the University of Cambridge. He specialises in how brain and genetic factors influence appetite and body weight regulation. He’s known for communicating complex science around obesity, appetite, and nutrition in an accessible way through media, books, and public talks.⚡️In this episode, Giles and I dig into how our genes - especially those in the brain’s appetite and reward centres - shape our hunger signals, fat storage, and body fat “set‑points”. We explain why diets often fail and how to reset our appetite.🎧 Stay tuned to find out:➡︎ Just how strongly our genes are to blame for appetite and body weight➡︎ The specific brain region that regulates hunger and energy balance➡︎ Whether weight loss injections are really the answer➡︎ Why obesity is biological - not a moral failing➡︎ The 3 numbers to remember for weight loss📕 Chapters(00:47) Welcome back(01:01) The genetic reason for obesity(02:49) The role of the brain in weight gain(05:15) Reward, hunger and fullness(08:14) How fat cells influence how hungry you are(10:09) The hypothalamus map(13:19) What to do when your meal’s not enough(16:16) Why hormones don’t limit your appetite(18:21) The paradox of leptin resistance(20:55) Insulin resistance and weight gain(22:30) Defining high quality weight loss(24:56) The yo-yo effect(26:13) Why weight loss drugs aren’t enough(30:17) The wider benefits of GLP-1 agonist weight loss drugs(34:19) Gene mutation and obesity(37:43) Gut hormones and the role they play(41:06) The effect of early years education(44:30) Three numbers to remember(46:23) Your DNA isn’t your destiny📱 Connect with me:Instagram: https://www.instagram.com/drkaranrajanYouTube: https://www.youtube.com/@DrKaran TikTok: https://www.tiktok.com/@dr.karanr📱 Connect with Dr Giles Yeo:Instagram: https://www.instagram.com/gilesyeoX: https://x.com/GilesYeo 📕 Grab Giles’ book here: https://amzn.eu/d/hoAnVLr 🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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47:37
How To Stop Eating Ultra-Processed Food with Rhiannon Lambert
💬 Rhiannon Lambert is a nutritionist and author of newly released book “The Unprocessed Plate: Simple, Flavourful UPF-free Recipes to Transform Your Life”.⚡️In this episode Rhiannon and I unpack some of the more worrying stats around ultra-processed food, discuss practical advice on how you can stop over-eating and improve your nutrition easily - and add some much needed nuance to the subject.🎧 Stay tuned to find out:➡︎ Simple ways to swap out junk food for healthier, tastier options➡︎ Why back of pack calorie information can be wrong by up to 30%➡︎ How food marketing and UPFs are damaging children the most➡︎ The income issue of healthy eating - how 2.3 million people don’t have fridges ➡ Why a lack of food culture leads to worse health outcomes📕 Chapters(0:46) Understanding the stats: How UPF increases mortality risk(3:17) What is ultra-processed food?(5:08) 60% of our diets are ultra-processed: does it matter?(8:40) Why 2.8m people don’t have fridges(10:03) The psychology of over-eating(17:51) How food marketing is damaging children(21:20) How wrong are back of pack calorie labels?(23:46) Getting protein from UPF sources(27:29) Nutrients most affected by processing(32:30) The need for food culture(36:28) Where most people fall down with UPF over-eating(38:17) Simple whole food swaps to improve your diet📱 Connect with me:TikTok: https://www.instagram.com/drkaranrajanYouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr📱 Connect with Rhiannon:Instagram: https://www.instagram.com/rhitrition/ Website: https://www.rhitrition.com/ 📕 Buy Rhiannon's new book The Unprocessed Plate here: https://www.amazon.co.uk/Unprocessed-Plate-Flavourful-UPF-free-Transform/dp/0241752655🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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44:19
Fibre: The Most Important Nutrient You’re Not Getting Enough Of | Gabrielle Palmeri
💬 Gabrielle Palmeri is a nutritionist, gut health dietician and self-professed fibre freak. She’s seen first hand the rising rates of colon cancer, especially in younger people, linked directly to poor fibre intake. ⚡️In this episode Gabrielle and I explore our mutual love of fibre and its amazing health benefits, and explain how you can easily up your intake.🎧 Stay tuned to find out:➡︎ The incredible number of health benefits you get from upping your fibre➡︎ Why fibre diversity is just as important as upping the amount you’re eating➡︎ How new research shows we seriously need to rethink fibre guidelines ➡︎ Easy recipe tips to make delicious, fibre-rich snacks and meals➡ Whether gut health snacks and fibre sodas are worth your money📕 Chapters(0:43) Why fibre is so significant(1:36) How much fibre are we actually eating?(3:59) How to eat more fibre without feeling overwhelmed(6:18) Build your fibre intake up slowly(8:40) Solution vs insoluble fibre(11:53) Do fibre enriched gut health sodas work?(14:27) How fibre helps weight loss(18:11) Why colon cancer is on the rise(22:53) What’s better, high fibre or diversity?(24:17) Why fibre guidelines need to be updated(29:04) Signs your body is low on fibre(31:19) Quickfire questions(34:32) Easy fibre meals(36:21) Biggest fibre myth📱 Connect with me:TikTok: https://www.instagram.com/drkaranrajanYouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr📱 Connect with Gabrielle:Instagram: https://www.instagram.com/dietitian.gabrielle/?hl=enWebsite: https://stan.store/dietitiangabrielleYouTube: https://www.youtube.com/@dietitian.gabrielleTikTok: https://www.tiktok.com/@dietitian.gabrielle?lang=en🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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37:48
What Every Woman Needs to Know About PCOS | Cory Ruth
💬 Cory Ruth is a registered dietitian and women’s health expert. As someone who suffers from PCOS, she has an intimate knowledge on the subject - and has dedicated her life to learning about the condition.⚡️In this episode Cory and I dig into the science of PCOS and the dietary and lifestyle strategies that can help women take control of their health, weight and vitality - and heal their bodies.🎧 Stay tuned to find out:➡︎ The common signs and symptoms of PCOS - and what doctors often miss➡︎ Why PCOS isn’t just a gynecological condition - it’s a whole-body condition➡︎ The link between gut health, insulin resistance and hormones➡︎ The food you should eat more of - and what you should avoid➡ The supplements that are actually worth your money for treating PCOS📕 Chapters(0:40) The science of PCOS & Cory’s health journey(5:00) The insulin resistance connection(7:28) Why PCOS is so easily dismissed by health pros(10:57) Not just a gynecological condition(14:05) Diet & how to eat with PCOS(18:43) The problem of ultra-processed food(21:13) How stress impacts PCOS(24:17) The role of supplements(27:33) Lab tests you should run(30:36) Can Ozempic help?(33:41) How to advocate for yourself as a patient(37:34) Advice for the person newly diagnosed with PCOS📱 Connect with me:TikTok: https://www.instagram.com/drkaranrajanYouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr📱 Connect with Cory:Instagram: https://www.instagram.com/thewomensdietitian/ Website: https://www.thewomensdietitian.com/about 🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
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41:42
What We Get Wrong About Race, Feminism & Identity | Blair Imani Ali
💬 Blair Imani Ali is an author, historian and the creator of Smarter In Seconds, an online series that is helping change people’s perspectives on issues of politics, identity, race, health and more.⚡️In this episode Blair and I delve into common biases that impact society, how we’re conditioned to think and feel the way we do, and how to find nuance in a polarised world of social media.🎧 Stay tuned to find out:➡︎ The difference between race, ethnicity, and nationality➡︎ How racism affects the healthcare people receive➡︎ What featurism is and why we make snap judgements about people➡ Why feminism has developed a negative image - and what it’s really about➡︎ How social media is hijacking our brains - and what to do about it📕 Chapters(1:00) The difference between race, ethnicity, and nationality(8:20) Health impacts of racial biases and stereotypes(19:25) Featurism - why we make snap judgements(24:52) What feminism is really about(32:51) Blair’s ADHD journey(40:07) Living a non-traditional life(44:57) How social media hijacks our brains📱 Connect with me:TikTok: https://www.instagram.com/drkaranrajanYouTube: https://www.youtube.com/@DrKaran Instagram: https://www.tiktok.com/@dr.karanr📱 Connect with Blair:Instagram: https://www.instagram.com/blairimani/ YouTube: https://www.youtube.com/blairimani 🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 🎙️ An OG Podcasts production.
Join Dr Karan as he meets the world's foremost experts in science and medicine to cut through the BS of modern health advice.
Get my free weekly newsletter filled with easy to action health tips, interesting facts & science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
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