In this nearly 2.5-hour episode, Dr. Rhonda Patrick and Dr. Roger Seheult and Kyle Allred of MedCram make a thoughtful, merit-based, and truly comprehensive discussion of COVID-19 vaccination. In addition to being a co-founder of MedCram Medical Lectures, Dr. Roger Seheult is, as you will find out in the conversation, a boots on the ground, critical care pulmonologist. For Dr. Seheult, COVID-19 is not just theory. He sees real sick people and for that reason brings a very special context to this conversation. Furthermore, Dr. Seheult is also an academic and educator. He is an Associate Clinical Professor at the University of California, Riverside School of Medicine and an Assistant Clinical Professor at the School of Medicine and Allied Health at Loma Linda University. He is quadruple-board certified in Internal Medicine, Pulmonary Diseases, Critical Care Medicine and Sleep Medicine through the American Board of Internal Medicine. In this episode, we discuss: 06:58 - Vaccination in the young and healthy 12:25 - Risk of myocarditis 16:18 - Long-haul COVID 25:36 - Spike protein cytotoxicity 34:16 - Biodistribution 41:17 - COVID-19 Vaccine Adverse Event Reporting System (VAERS) 01:06:55 - Antibody-dependent enhancement 01:14:54 - Do the COVID-19 vaccines damage human fertility? 01:19:51 - mRNA vaccines altering human DNA 01:28:10 - Current ivermectin evidence 01:47:40 - Delta-variant and breakthrough infections 02:01:42 - Viral evolution (virulence vs. immune escape) 02:10:45 - T-cell immunity vs. antibody immunity Watch the annotated video: https://www.youtube.com/watch?v=pp-nPZETLTo Subscribe to MedCram on Apple Podcasts: https://podcasts.apple.com/us/podcast/medcram/id1564795918 Subscribe to MedCram on YouTube: https://www.youtube.com/channel/UCG-iSMVtWbbwDDXgXXypARQ

Dr. William ("Bill") Harris is one of the world's preeminent experts in the field of omega-3 fatty acid research. His work has focused on the roles that fatty acids in play in cardiovascular and neurocognitive health. The author of more than 300 scientific papers on fatty acids and health, Dr. Harris is a professor in the Department of Medicine in the Sanford School of Medicine at the University of South Dakota, the co-inventor of the Omega-3 Index, founder of OmegaQuant Analytics, and president and founder of the Fatty Acid Research Institute. In this episode, Dr. Harris and I discuss… 00:06:36 How early studies on dietary fats and cholesterol levels spawned the field of omega-3 research. 00:14:44 How standards of "normal" bleeding time may be abnormally high in Western countries, leading to some misconception on the effects of omega-3. 00:20:33 How different types of omega-3s, such as alpha-linolenic acid, share structural similarities with marine omega-3s but not the same cardioprotective effects. 00:25:23 How genetic engineering of plants may yield abundant, sustainable omega-3s in the future. 00:27:18 What the omega-3 index test is, how it was created, and how it reveals individual variations in how much omega-3 we may need. 00:32:13 How red blood cell concentration of omega-3s better reflect long-term omega-3 status. 00:36:41 How genetic variants influence omega-3 dietary needs. 00:54:20 How the omega-3 index may predict life expectancy. 01:05:03 How metabolites of omega-3 metabolism reduce and resolve inflammation. 01:17:11 How people with high omega-3 concentrations were half as likely to die from COVID-19. 01:20:10 How the omega-3 DHA may help keep the SARS-CoV-2 spike protein from entering cells. 01:22:50 How concerns over the omega-6/omega-3 ratio may be unfounded, and it really may boil down to just how much omega-3 you're taking in.   Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Ashley Mason is a clinical psychologist and director of the Sleep, Eating, and Affect Laboratory at the Osher Center for Integrative Medicine at UCSF. Her research centers on nonpharmacological approaches for treating depression, insomnia, and overeating. In this episode, you’ll hear Rhonda and Ashley discuss: 00:08:10 - How whole-body hyperthermia (WBH) and sauna use differ.  00:17:06 - How people with depression have thermoregulatory dysfunction – but sauna use may correct it. 00:21:12 - How WBH and sauna use may reduce symptoms of depression. 00:33:22 - How heating the body slowly may improve heat tolerance and increase WBH effectiveness.  00:39:35 - How sauna use may benefit people with depression and cardiovascular disease – which often coincide.  00:40:18 - How Dr. Mason and I are collaborating on a new research project to measure biomarkers associated with depression and WBH. 00:44:19 - How sauna bathing and similar practices often provide opportunities for people to connect socially.  00:53:12 - How insomnia differs from being a "night owl." 00:57:10 - How insomnia often arises from major changes in a person's life.  01:01:26 - How cognitive behavioral therapy, sleep hygiene, stimulus control, and sleep restriction can help treat insomnia without drugs.   and so much more!   Looking for more?  Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, Dr. Mattson and I discuss... 00:3:31 How hormetic stressors drive adaptation and prevent physiological complacency. 00:13:00 How intermittent fasting improves health by promoting metabolic switching. 00:16:49 How daily time-restricted eating and 5:2 weekly fasting compare. 00:27:44 How a ketogenic diet and intermittent fasting differ in terms of brain effects. 00:34:23 How exercising while intermittent fasting exerts additive effects. 00:52:32 How plant-based bioactive compounds induce hormetic stress. 01:10:48 How severe caloric restriction may harm the body and compromise muscle mass. 01:26:25 The differing contexts of intermittent fasting: young vs. old and in men vs. in women. 01:35:20 How the effects of cortisol differ during a fast versus chronic uncontrollable stress. 01:53:36 How the effects of fasting-mimetics like resveratrol and spermidine compare with actual fasting, and; 02:08:44 How ketone supplementation may improve brain health   Show notes coming soon! Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Dr. Satchin Panda Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies.  Dr. Panda’s work focuses on chronobiology, the study of the day-night cycles that drive the multifaceted activities of the human body, using genetic, genomic, and biochemical approaches. He is an expert on circadian rhythms and a pioneer in the field of time-restricted eating. A priority for Dr. Panda when designing his studies is to identify strategies that positively impact public health. In this episode, Dr. Panda and I discuss... 00:05:31 How circadian rhythms influence human health. 00:12:30 How seeking bright light in the morning and avoiding it in the evening can help us sleep better. 00:20:40 How the ability of supplemental melatonin to counteract evening bright light exposure varies. 00:26:16 How understanding the relationship between melatonin and insulin secretion might help us decide when to eat. 00:33:15 How shift work, jet lag, and modern lifestyles contribute to altered circadian rhythms and metabolic dysfunction. 00:45:10 How naps might aid with afternoon sleepiness and sleep loss. 00:47:05 How we can tailor our indoor lighting environment to promote healthy circadian rhythms. 00:51:20 How time-restricted eating (eating within a narrow time range) can be beneficial. 01:02:13 How Dr. Panda’s ongoing study uses a smartphone app to track when people eat. 01:03:41 How most people are unaware of their eating patterns. 01:07:58 How Dr. Panda incorporates his research findings into his own life. 01:16:21 How our circadian rhythms dictate when we should exercise – and how caffeine provides a workaround.   If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/satchin-panda-3 Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor