#103 A Deep Dive on Using Coffee For Health & Longevity (Full Guide & Research)
Get access to more than 120 episodes of my premium podcast, The Aliquot, as a FoundMyFitness Premium Member Coffee is one of the most powerful longevity tools we have, potentially reducing epigenetic age by up to one year in regular coffee drinkers, but its effectiveness hinges entirely on how you brew it. In this episode, I outline precisely how coffee reduces DNA damage, a key driver of cancer and cellular aging, and why choosing filtered coffee over methods like French press significantly lowers cholesterol risk. I’ll discuss exactly which beans and roasts pack the highest antioxidant punch, plus a practical tip on a specific supplement that amplifies coffee’s cognitive benefits. You’ll also learn the truth about mycotoxins in coffee and why adding dairy can blunt coffee’s immediate cognitive-boosting effects. Timestamps: (00:00) Introduction (01:24) Can coffee really slow biological aging? (04:42) Is coffee actually protective for your heart? (05:27) Why morning coffee is healthier than afternoon coffee (08:01) How coffee improves your metabolic health (09:52) Can coffee reduce cancer risk? (11:25) Does coffee protect DNA from damage? (13:38) Can coffee enhance your gut microbiome? (16:01) Can unfiltered coffee raise your cholesterol? (20:13) Which brewing method maximizes antioxidants? (20:40) Arabica or robusta—does bean type matter? (23:04) Dark vs. light roast—what’s richer in antioxidants? (23:28) Is cold brew coffee as healthy as hot coffee? (23:51) Practical tips to maximize antioxidants (24:38) Filtered vs. French press—what’s best for longevity? (26:48) Can espresso’s antioxidants offset its cholesterol risk? (27:18) Instant coffee—an overlooked longevity booster? (27:40) Why filtered coffee is the clear winner (28:20) Caffeinated vs. decaf—what’s better for your brain? (30:42) Can decaf coffee still enhance cognitive function? (33:38) How much caffeine is optimal for athletic performance? (36:31) How decaffeination methods affect coffee’s benefits (39:02) Are mold toxins in coffee really a concern? (41:45) Is adding dairy a mistake? (43:15) Does MCT powder boost cognition—or just cholesterol? (44:59) Does adding L-theanine reduce caffeine-induced anxiety? (47:04) The science-backed coffee routine for longevity Show notes, transcript, and summary are available by clicking here Watch this episode on YouTube
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#102 Why Vitamin D Deficiency Accelerates Brain Aging
Discover my premium podcast, The Aliquot Vitamin D is far more than just a vitamin—it's a potent steroid hormone regulating nearly 5% of our genome. Yet, remarkably, up to 70% of Americans aren't getting enough, placing them at increased risk for dementia and Alzheimer's disease. In this episode, I explore compelling new evidence from a study involving over 12,000 participants, demonstrating that vitamin D supplementation can reduce dementia risk by an impressive 40%, protecting even adults with genetic Alzheimer's risk (ApoE4 carriers). Timestamps: (00:00) Can vitamin D supplements reduce dementia risk? (00:46) How common is vitamin D deficiency? (03:31) What studies reveal about genes, vitamin D, and dementia (05:44) Does deficiency accelerate brain aging? (06:45) Can vitamin D supplementation enhance cognitive function? (08:15) Dementia risk reduction insights from 12,388 adults (09:58) Why women may benefit most (10:49) Normal vs. impaired cognition—who benefits more from vitamin D? (11:21) Do ApoE4 carriers get dementia protection from vitamin D? (13:00) How mild cognitive impairment affects dementia risk (13:41) Does the form of vitamin D matter? (14:11) What are the optimal vitamin D blood levels? (15:07) What dose corrects deficiency? (15:33) How vitamin D directly supports brain function Watch this episode on YouTube Show notes are available by clicking here The study discussed: Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
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#101 Dr. Andy Galpin: The Optimal Diet, Supplement, & Recovery Protocol for Peak Performance
Download my “How to Train According to the Experts” guide Discover my premium podcast, The Aliquot Nutrition, supplementation, and recovery are foundational for enhancing exercise performance, but their full potential often remains untapped. In this episode, Dr. Andy Galpin, a renowned expert who has coached Olympians, world champions, and professional athletes across major sports, breaks down exactly how to leverage these critical elements to meaningfully enhance your results. Timestamps: (00:00) Introduction (05:01) Eating to perform vs. eating to live longer—do you have to choose? (08:20) Training fasted—are the mitochondrial benefits worth it? (14:53) What should you eat before early-morning strength training? (16:52) Why nutrient timing isn't critical for the average exerciser (18:44) Is intermittent fasting killing your gains? (29:24) Carbs before resistance training—fuel or fluff? (31:07) Endurance fueling strategies—what actually works? (36:02) When is post-exercise carb intake truly essential? (37:35) Game day fueling—how to get it right (40:25) Carb supplements vs. whole foods—what do elite athletes actually eat? (43:18) Rethinking fat intake for exercise performance (46:14) Metabolic flexibility—how the term got hijacked (50:39) The real test of metabolic health—why skipping a meal shouldn't break you (51:55) Are anaerobic and aerobic systems truly separate? (55:56) Does protein timing really matter? (58:27) Whole foods vs. protein powders (1:03:21) Fat timing—overlooked or irrelevant? (1:04:48) The truth about seed oils and saturated fat (1:09:43) Magnesium—who actually needs to supplement? (1:11:43) The problem with magnesium blood tests (1:13:01) Why the magnesium RDA might not be enough (1:13:54) Magnesium citrate, glycinate, or threonate—does it matter? (1:15:55) Do magnesium supplements really aid recovery? (1:18:35) Omega-3 supplementation—is the AFib risk real? (1:22:10) Can omega-3s prevent muscle loss during inactivity? (1:26:14) Why "performance anchors" matter more than supplements (1:30:47) Iron deficiency—the hidden performance killer? (1:33:42) Does caffeine before workouts increase fat burning? (1:35:29) Caffeine cycling—smart strategy or outdated myth? (1:38:45) Can music measurably enhance workout performance? (1:39:57) Rhodiola rosea—fatigue fighter or placebo? (1:44:38) Beetroot, citrulline, arginine—do nitric oxide boosters work? (1:55:07) Beta-alanine—why the tingles might be worth it (2:01:05) Is 5g of creatine really enough? (2:02:18) Sodium bicarbonate—effective fatigue buffer or GI nightmare? (2:04:36) Can you trust what's in your pre-workout supplement? (2:06:54) Is too much caffeine killing your performance gains? (2:07:41) Can antioxidants blunt exercise performance? (2:08:40) High-dose vitamin C—immune protection or adaptation killer? (2:15:12) Do anti-inflammatories sabotage your gains? (2:17:38) Tart cherry juice—recovery aid or overhyped? (2:21:04) Is glutamine the immune booster athletes need? (2:29:11) Can collagen actually strengthen tendons? (2:33:26) Does glucosamine chondroitin actually help joints? (2:34:28) What really happens during recovery—signaling vs. inflammation (2:37:25) The most important recovery metric (2:39:05) How increased blood flow accelerates muscle repair (2:43:55) Why persistent soreness might mean your fascia's at fault (2:47:02) Can compression boots genuinely speed recovery? (2:47:56) Can simply soaking in water accelerate recovery? (2:51:13) When is sauna a better choice than extra miles? (2:53:12) Can localized heat preserve muscle during downtime? (2:54:31) Cold immersion timing—muscle recovery vs. blunting gains (3:01:16) Why pre-bed cold exposure might improve sleep (3:04:31) Heart rate variability vs. resting heart rate (3:12:45) Why respiratory rate predicts stress better than resting heart rate (3:16:57) Are you overtrained—or just overreached? (3:21:41) Hormones and overtraining—what's the real link? (3:25:48) Does training harder mean you need more sleep? (3:27:54) How to know if you're getting enough sleep (3:31:17) Sleep trackers (3:33:10) Hydration timing—the key to uninterrupted sleep? (3:34:54) Why your wind-down index matters (3:36:02) Is your bedroom's CO₂ buildup sabotaging your sleep? (3:39:40) Are nasal allergies quietly wrecking your recovery? (3:41:23) Sleep hacks—what actually works? Watch this episode on YouTube Show notes are available by clicking here
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#100 The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
Download my “How to Train According to the Experts” guide Discover my premium podcast, The Aliquot Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine’s diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects. Timestamps: (00:00) Introduction (04:34) What makes creatine effective for exercise performance? (08:01) The loss of explosive power with aging (09:36) How creatine speeds up recovery between sets (12:13) Two ways creatine boosts muscle strength (14:12) Why creatine might not speed typical weight-training recovery (16:38) Anti-catabolic effects (17:16) Why do men and women respond differently? (18:50) Dietary creatine vs. supplementation (19:36) Is creatine supplementation necessary—or optional? (21:05) Why plant-based may benefit most (22:15) Should creatine dosage change with age? (23:01) Loading vs. daily dosing (25:57) Why 5 grams might not be enough—other tissues (27:48) Can creatine prevent bone loss—even without weight training? (28:10) How creatine supports osteoblast activity (29:51) Preventing hip fractures with creatine (32:33) Creatine vs. bisphosphonates (36:21) Why creatine isn’t just for weightlifters (38:52) Why stressed brains benefit most (40:57) Why brain aging accelerates demand (43:54) Why 10g per day might be the optimal dose (45:45) Why creatine counteracts sleep deprivation (48:53) Before vs. after concussion (51:17) Should dosage be adjusted by weight? (52:39) Does creatine improve sleep on training days? (55:34) Creatine for Alzheimer’s and Parkinson’s—does the science hold up? (57:08) Can creatine help with depression and anxiety? (1:00:24) The role of creatine and glutamine in preventing respiratory illness (1:02:40) Why creatine may enhance endothelial health and circulation (1:04:04) Creatine’s role in cardiometabolic health (1:05:45) When does loading actually make sense? (1:06:51) Creatine’s dual role—preserving muscle and enhancing recovery after injury (1:09:46) Is creatine effective without exercise? (1:12:01) Why creatine might improve male fertility (1:13:57) Is it safe for children? (1:17:21) Creatine supplementation during pregnancy (1:18:54) Could creatine boost motor skills in kids? (1:19:34) Creatine monohydrate vs. the rest (1:24:15) How to avoid digestive issues with creatine supplementation (1:26:56) Does timing matter—and should you cycle it? (1:28:32) Should you take creatine every day—or only workout days? (1:29:17) Why caffeine might blunt the effects (1:32:21) Does creatine increase body fat—or is that a myth? (1:33:08) Preventing cramps (the hydration myth) (1:34:33) Understanding the creatinine confusion—why creatine won’t damage your kidneys (1:36:59) Why creatine is linked (wrongly?) to baldness (1:40:22) Debunking myths—sleep, cancer, urination (1:43:39) How creatine affects homocysteine levels (1:46:32) Creatine and protein—the ideal post-workout pair? (1:49:26) How to pick the best creatine supplement (1:51:46) What to know about micronized creatine Watch this episode on YouTube Show notes are available by clicking here
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#099 The Science of Exercise for Cancer | Kerry Courneya, PhD
Download my “How to Train According to the Experts” guide Discover my premium podcast, The Aliquot For decades, exercise was considered an optional part of cancer care—something beneficial for general health but not essential. The evidence is now overwhelming: exercise is not just supportive—it’s a therapeutic intervention that recalibrates tumor biology, enhances treatment tolerance, and improves survival outcomes. With over 600 peer-reviewed studies, Dr. Kerry Courneya's work has fundamentally reshaped our understanding of how structured exercise—whether aerobic, resistance training, or high-intensity intervals—can mitigate treatment side effects, enhance immune function, and directly influence cancer progression. Timestamps: (00:00) Introduction (04:31) Why exercise should be effortful (05:17) How to meaningfully reduce risk of cancer (09:06) What type of exercise is best? (10:43) How exercise reduces risk—even for smokers and the obese (13:32) Weekend-only exercise (16:33) 150 vs. 300 minutes per week (more is better—up to a point) (18:47) Why pre-diagnosis exercise matters (21:53) Why resilience to cancer treatment starts with exercise (23:45) Why low muscle mass drives cancer death (26:42) Why BMI fails to measure true obesity (30:35) Why daily activity isn't enough (structured exercise matters) (32:18) Breaking up sedentary time—do 'exercise snacks' help? (34:34) Supplements vs. exercise (35:16) Where exercise fits with chemo and immunotherapy (38:14) Why rest is not the best medicine (44:04) Aerobic vs. resistance (44:57) How weight training improves 'chemo completion' (47:25) Why exercise creates vulnerability in cancer cells (limitations do apply) (49:53) Why exercise might be crucial for tumor elimination (55:47) Why cardio may be better at clearing tumor cells (59:02) When cancer spreads quickly—and when it doesn't (1:00:27) Why liquid biopsies may prevent over-treatment (1:05:40) Exercise-sensitive vs. exercise-resistant cancers (1:08:50) Prostate cancer therapy—why strength training matters (1:10:54) When exercise is the only therapy—does it work? (1:12:10) Why HIIT reduces PSA in prostate cancer (1:14:24) Avoiding overtreatment—can exercise buy you time? (1:14:44) Why high-intensity exercise boosts anti-cancer biology (1:15:55) Turning a diagnosis into a wake-up call (1:18:55) Why oncologists are rethinking exercise (1:21:34) Why exercise eases anxiety about cancer—proven psychological benefits (1:27:44) Before, during, and after treatment (1:29:46) Why exercise is unique among cancer therapies (1:31:00) Why cancer patients stop exercising—the risky mistake almost everyone makes (1:33:25) How to get sedentary cancer patients exercising (realistically) (1:35:59) The $1 million per patient case for including exercise (1:37:40) Why recurrence trials haven't convinced doctors—yet (1:40:20) The bottom-line message (1:40:39) The myth of a cancer panacea (exercise included) (1:46:51) What's the best $50 investment for staying active? (1:47:24) Only 15 minutes per day—what's the best anti-cancer exercise? Show notes are available by clicking here Watch this episode on YouTube
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