George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.  In this episode, we discuss: 07:13 - History of the Human Genome Project 15:20 - Manufacturing cell phones (with biology) 17:34 - Genome Project-Write 20:03 - Writing a human Y chromosome (from scratch) 20:48 - What if you could eliminate viral disease? 22:51 - De-extinction and reinstating lost traits and genes 27:06 - The Vertebrate Genomes Project 29:47 - AlphaFold and other AI tools 41:27 - CRISPR vs. Base Editing (emerging tools of genetic engineering) 49:40 - Why multiplex editing will change the world 52:18 - Molecular flight recorder 53:31 - Preventing viral spillover and enhancing livestock 57:40 - PCSK9 gene therapy for cholesterol 01:00:30 - Is aging an evolved program? 01:05:21 - Treating aging with a combination gene treatment 01:09:04 - Does animal research help us understand human aging? 01:11:40 - Human organoids as a model and therapeutic 01:13:34 - Could engineered transplant organs become better than the originals? 01:16:17 - Embryo editing controversy 01:28:41 - Gene editing for space travel 01:30:40 - Can synthetic biology alleviate poverty? 01:34:07 - Is in vitro fertilization and embryo selection practically similar to editing? 01:39:12 - The occasional cost of brilliance 01:45:45 - Eradicating disease with Gene Drive 01:48:55 - Technologies to solve Lyme disease 01:51:57 - Dr. Church's experience with narcolepsy as a bridge to creative insights 02:00:42 - Why George encoded his book in DNA Watch this episode on YouTube Show notes are available by clicking here Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/premium Learn more about the premium podcast The Aliquot: https://www.foundmyfitness.com/aliquot

Stuart Phillips, PhD, is a professor of kinesiology at McMaster University in Hamilton, Ontario, Canada, where he also serves as the director of the Physical Activity Centre of Excellence. His research centers on the roles exercise and nutrition play in influencing human skeletal muscle protein turnover and how these lifestyle factors influence body composition, especially as we age. In this episode, we discuss: 00:07:16 - Why muscle is important for longevity 00:14:34 - Is the importance of muscle mass (per se) overstated? 00:16:48 - Is the RDA on protein too low? 00:19:03 - Minimum vs. optimal protein intake (for athletes) 00:19:29 - Why older adults need more protein 00:24:52 - Caloric restriction vs. higher protein for aging 00:28:04 - What is a catabolic crisis? 00:29:40 - Effects of space flight on muscle 00:36:16 - Practical tips for protein intake 00:39:34 - Protein timing and the anabolic window 00:41:27 - Most important factors for hypertrophy 00:43:57 - Should we supplement leucine? 00:45:46 - Does plant protein support hypertrophy? 00:56:30 - Causes of anabolic resistance 00:58:22 - What types of exercise and how much? 01:06:56 - Protein and rest as tools for recovery 01:08:14 - Mechanisms of muscle protein synthesis and breakdown 01:08:31 - Does rapamycin inhibit hypertrophy? 01:13:07 - What is Dr. Phillips doing to age well? 01:15:25 - Hormonal responses to exercise 01:17:09 - Sex differences in hypertrophy 01:19:38 - Effect of menopause on muscle 01:20:03 - Do testosterone boosters work? 01:21:56 - Does growth hormone improve muscle? 01:26:30 - Androgen replacement therapy (benefits vs. drawbacks) 01:31:17 - Mental health benefits of exercise 01:31:54 - Anti-catabolic effects of heat 01:38:19 - Molecular causes of sarcopenia 01:42:35 - Anti-catabolic effects of omega-3 01:48:57 - Brain and muscle effects of creatine Watch this episode on YouTube Show notes and transcript Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health – including cardiometabolic function, neurological health, behavior, and more – in surprising and unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators. Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 – 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease. Show notes and video CHAPTERS: 06:04 - Introduction 08:12 - Atherosclerosis 13:49 - Brain 16:07 - Circulating LPS and behavior 19:05 - Toll-like receptors and inflammation 24:00 - Factors that affect intestinal permeability 30:10 - Alcohol 32:07 - Gluten 35:21 - Butyrate and dietary fiber 37:48 - Dietary fat 42:21 - Biomarkers of intestinal permeability 43:11 - Omega-3 fatty acids 50:02 - Q&A LEARN MORE: Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode. Learn about the blood-brain barrier Learn about intestinal permeability Learn about toll-like receptors Learn about cerebral small vessel disease SUPPORT THE CHANNEL: Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of the FoundMyFitness platform. Become a member

Dr. Dominic ("Dom") D'Agostino is an expert on a wide range of topics related to metabolic health, ketosis, and ketogenic diets. As one of the world's foremost experts on the ketogenic diet, Dom has personally practiced some variation of ketogenic diet for over a decade, bringing a substantial amount of practical experience along with his anecdotes from human and animal research. In this episode, we discuss: 00:04:59 - What is "keto” (and what it is not) 00:08:42 - Types of ketogenic diets 00:15:27 - Lifestyle Ketogenic Diet 00:26:36 - Biomarkers and hyperlipidemia 00:29:41 - Micronutrients and Supplementation 00:33:40 - Exogenous Ketones 00:55:48 - Optimal blood concentration of ketones (Dom's pick) 01:13:31 - Exercise performance and anti-catabolic effects 01:34:37 - Brain and Memory 01:42:39 - Intermittent Fasting 01:51:43 - Neurodegenerative Diseases 01:58:05 - Migraines 02:04:17 - Autoimmune diseases 02:06:15 - Cancer 02:22:03 - Carnivore diet 02:28:22 - Dom's lifestyle habits 02:31:46 - Measuring ketones Watch this episode on YouTube: https://www.youtube.com/watch?v=RWkv9ad7zvc If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/dominic-dagostino-2 Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

This episode features a discussion with MedCram co-founder Kyle Allred on the effects of sauna. I had the pleasure of being interviewed by Kyle on all things sauna science and we're posting that discussion for you here. As an exercise mimetic, sauna use has anti-inflammatory, mood-elevating, and detoxifying properties that research increasingly shows may deliver cardiovascular and brain benefits. The science of sauna use has been a research interest of mine for many years and this discussion is by far one of the most well-rounded discussions I've had on the subject. Thanks to Kyle and MedCram for having me for his interview. In this episode, we'll discuss: 00:00:00 - Introduction 00:02:46 - Summary of sauna benefits 00:10:47 - Heat as an aerobic exercise mimetic 00:14:45 - Effects of heat acclimation on endurance 00:17:37 - Why heat shock proteins may protect against dementia 00:23:20 - The stress-relieving effects of sauna use (personal anecdote) 00:27:43 - Investigating sauna for depression 00:30:32 - Brain-derived neurotrophic factor (BDNF) and endorphins response 00:34:51 - Cellular repair mechanisms elicited by sauna use 00:40:05 - Prevention of muscle atrophy 00:42:45 - Detoxification of heavy metals  00:44:50 - Heart rate variability, a measure of stress resilience 00:46:40 - The synergy of sauna use and exercise 00:52:13 - Cross-cultural and historical prevalence of heat therapy 00:56:12 - Infrared sauna vs. traditional saunas 00:58:31 - Rhonda's personal sauna protocol: duration, temperature, humidity, and frequency 01:03:22 - How jacuzzi, hot baths, and hot showers compare to sauna use 01:06:19 - Hydration, cold therapy, and sauna safety  01:11:18 - Who should not use saunas? 01:15:21 - Does sauna use increase blood sugar levels? 01:17:16 - Limitations of current sauna research and hopes for future research MedCram is a YouTube channel created by Kyle Allred, PA-C and Roger Sehuelt, MD, master educators of health and medical science. Their videos cover important topics such as immunity, metabolism, and vitamin D in an authoritative, but approachable way. Visit the MedCram YouTube channel for more efficient, engaging, fun, and lasting way to learn and review medical topics. Watch this episode on MedCram:https://www.youtube.com/watch?v=RWkv9ad7zvc If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/medcram-sauna Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor