Modern Healthspan

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Leading hairrestoration surgeon Dr. Alan Bauman reveals the science behind hair loss,graying, and the evidence-based treatments that actually work—from medicationsto regenerative therapies.
Dr. Alan Baumanis a board-certified hair restoration physician who has treated over 30,000patients and performed 14,000+ hair transplants in his 28-year career. In thisconversation, we explore the biological mechanisms behind hair loss andgraying, why you can lose 50% of your hair density before noticing it, and thepractical interventions that work.
 
We discuss theevidence for medications like minoxidil and finasteride, regenerative therapiesincluding PRP and exosomes, low-level laser therapy, and the role of lifestylefactors like nutrition, stress, and sleep. Dr. Bauman explains genetic testingfor hair loss predisposition, the truth about DHT-blocking shampoos, whetherhair coloring damages follicles, and when to consider surgical options.
 
Key takeaway:"Time equals follicles"—early intervention is critical because oncehair follicles are damaged, reversal becomes increasingly difficult. Whetheryou're experiencing thinning or want to protect your hair long-term, thisepisode provides actionable, science-based strategies.
🌐Links in this video
Bauman Medical website https://www.baumanmedical.com/
LinkedIn https://www.linkedin.com/in/alanjbauman/
Instagram https://www.instagram.com/baumanmedical/

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Dr. Henry Mahncke reveals how an NIH-funded study showed brain training reversed brain aging markers by 10 years, why speed-based training is uniquely effective, and the future of brain health interventions.
Dr. Henry Mahncke, CEO of Posit Science and creator of BrainHQ, discusses the groundbreaking INHANCE study that used PET scans to show brain training can reverse brain aging by 10 years. In this wide-ranging conversation, Dr. Mahncke explains how their adaptive brain training exercises increase acetylcholine—a crucial neurochemical that declines with age and is depleted in Alzheimer's disease. He addresses common criticisms of brain training, explaining why speed and accuracy training is fundamentally different from memorization exercises, and shares surprising insights including why Tom Brady uses brain training. We discuss optimal dosing (30 minutes daily works well), the role of sleep in brain plasticity, supplementation with compounds like phosphatidylcholine, and whether this should be a lifelong practice. Dr. Mahncke makes the case that we're at the beginning of a "brain health revolution" where maintaining cognitive function should be as routine as physical exercise

🌐Links in this video
Brain HQ website https://www.brainhq.com/ The trial on clinical trials https://clinicaltrials.gov/study/NCT04149457 Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial https://games.jmir.org/2025/1/e75161

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory.

Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he's turned his attention to longevity, and he's not just theorizing. Dr. Cramer is participating in Mitrix's groundbreaking mitochondrial transplantation trial, which aims to replace damaged mitochondrial DNA with healthy versions grown in bioreactors.

In this conversation, Dr. Cramer explains why he believes mitochondrial dysfunction is the root cause of aging, not just another hallmark. He discusses how energy depletion cascades into all other aging symptoms, why previous interventions like telomere extension haven't delivered, and what markers will be tracked throughout his trial. He also shares his personal longevity protocol, including rapamycin, senolytics, and hyperbaric oxygen therapy.

This is one of the first detailed discussions of autologous mitochondrial transplantation for aging in humans.
🌐Links in this video
Mitrix Bio website https://mitrix.bio

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.

Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.
The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.
Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.
This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.

🌐Links in this video
Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/38956196/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.

In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.

Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.
He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.

🌐Links in this video
Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner
X (Twitter) https://x.com/CharlesMBrenner/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan