Modern Healthspan

Discover how the "Brain Energy Gap" drives cognitive decline and how ketones can rescue starving neurons. Dr. Stephen Cunnane explains the science of metabolic health, the BENEFIC trial, and how to fuel a hybrid brain for long-term longevity.
Is Alzheimer’s actually a fuel shortage in the brain? In this interview, world-renowned researcher Dr. Stephen Cunnane breaks down the "Brain Energy Gap", a critical metabolic deficit where the brain loses its ability to utilize glucose efficiently as we age. While this energy gap can lead to Mild Cognitive Impairment (MCI) and Alzheimer’s, Dr. Cunnane’s groundbreaking research, including the landmark BENEFIC trial, shows that ketones can bypass this blockage to provide a vital backup fuel source.

We dive deep into the hybrid brain concept, exploring how Medium Chain Triglycerides (MCTs) and specific dietary shifts can "rescue" cognitive function by doubling brain ketone uptake. Dr. Cunnane also discusses the "double jeopardy" of insulin resistance and why managing metabolic health is the most promising frontier for preventing neurodegeneration. Whether you are interested in brain health, longevity, or the clinical applications of ketogenic metabolic therapy, this technical deep dive offers essential insights into the future of healthy aging

🌐Links in this video
A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT https://pmc.ncbi.nlm.nih.gov/articles/PMC8048678/ Improved brain energetics and cognition after a 6-month ketogenic intervention in mild cognitive impairment: Final results of the Benefic Trial https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.037961 A reduced carbohydrate diet improves glycemic regulation in hyperglycemic older people in a retirement home: the SAGE study https://cdnsciencepub.com/doi/10.1139/apnm-2024-0277

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Muscle scientist Dr Brad Schoenfeld on how to stay strong after 60.
Dr Brad Schoenfeld is a professor of exercise science at Lehman College, New York, and one of the world's most cited researchers on muscle hypertrophy. In this interview we cover the practical science of building and maintaining muscle as you age with a focus on what actually matters for healthspan and independence.
We discuss how much training older adults really need, why power matters more than strength for fall prevention, and how to think about loads and reps after 60. Brad also explains why protein requirements increase with age, what the leucine threshold is and why it matters, and gives his frank assessment of the supplement landscape including the one he thinks has genuine evidence behind it.
We also touch on VO2 max, balance, flexibility and the role of consistency. A practical, evidence-based conversation for anyone serious about staying strong and independent as they age.

🌐Links in this video
Dr Schoenfeld's page https://www.lehman.edu/academics/health-human-services-nursing/exercise-sciences-recreation/bradley-schoenfeld/

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Dr. Howard Sesso of Harvard explains the results of the COSMOS trial, identifying who actually benefits from a daily multivitamin and how it impacts biological aging.
Is a daily multivitamin a life-extending "insurance policy" or just a waste of money? In this clip, Dr. Howard Sesso, Co-Principal Investigator of the landmark COSMOS trial, breaks down the clinical evidence from over 21,000 participants. We explore the "sweet spot" of nutritional insufficiency; where you aren't clinically deficient but lack the levels needed for optimal healthspan.

Dr. Sesso and Dr. Sidong Li discuss how multivitamins specifically slowed the "epigenetic clock" in individuals with existing risk factors like hypertension and accelerated biological aging. We also cover the importance of "precision nutrition" and why the synergy of essential vitamins and minerals may be more effective than high-dose single supplements. If you’re looking for a common-sense, evidence-based approach to basic supplementation, this deep dive into the Harvard-led COSMOS data provides the answers you need.

🌐Links in this video
COSMOS Trial home page https://cosmostrial.org/ Effects of daily multivitamin–multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial https://www.nature.com/articles/s41591-026-04239-3

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Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells.
Dr. Amit Sharma leads the senescence immunology group at the Lifespan Research Institute, where his lab studies how natural killer cells and gamma delta T cells interact with senescent cells — and how that relationship breaks down with age. In this conversation, we explore the biology of immune surveillance of senescence, why it fails as we get older, and what his lab is doing to restore and enhance it. We also discuss the iron-ferroptosis connection, next-generation senolytics, and what the next decade might bring for senotherapy.

🌐Links in this video
Lifespan Research Institute: https://lifespanresearchinstitute.io
Dr Sharma's lab page https://lifespan.io/our-research/sharma-lab/
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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan
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Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly.
Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, including why they get the same diseases as the rest of us, just decades later, and what that means for the goal of longevity medicine. We then move into the practical territory: what criteria distinguish a drug that treats one disease from one that may target aging itself, which four currently approved drugs score highest on that framework, and how leading longevity physicians are beginning to use them in practice. We also discuss GLP-1 agonists in depth; their mechanisms, the emerging evidence for benefits well beyond weight loss, and the important caveats around muscle loss. Essential viewing for anyone following the science of healthy aging.

🌐Links in this video
Dr Barzilai at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/484/nir-barzilai Healthy Longevity Medicine Society https://hlms.co/ American Federation for Aging Research https://www.afar.org/ Academy for Health & Lifespan Research https://www.ahlresearch.org/

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