Energized with Dr. Mariza

Why are so many women waking up exhausted… but unable to shut their brain off?”

In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife.

Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood.

They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again.

If you’ve been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle.

Dr. Scott Sherr

Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support.

IN THIS EPISODE

Why so many women feel “wired and tired” in perimenopause

The real reason behind 2–3 AM wakeups and racing thoughts

How GABA, cortisol, serotonin, and adenosine impact sleep and stress

Why nervous system regulation is essential for resilience and recovery

The connection between mitochondrial health, energy, and brain function

How chronic stress and sympathetic overload affect hormones and mood

Practical tools to support sleep, focus, calm, and nervous system balance

QUOTES

“Sleep will make or break you the next day—especially in this season of life.”

“To increase your performance is having more reserve.”

“You’re not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.”

RESOURCES MENTIONED

Use code ENERGIZED and get 10% off on your Troscription Order

http://troscriptions.com/ENERGIZED

Use code ENERGIZED and get 10% off on your MitoQ Order

https://www.mitoq.com/energized%C2%A0

Troscriptions Website

Dr. Scott Sherr Instagram

Dr. Scott Sherr Youtube

RELATED EPISODES 

744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now

717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It

593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

“Is this brain fog… or something more?”

In this solo episode, Dr. Mariza unpacks the hidden neurological and metabolic shifts happening during perimenopause and menopause—and why so many women suddenly feel mentally “off.”

From brain fog and memory lapses to anxiety, overwhelm, and lower stress resilience, these symptoms are often dismissed as aging or stress. But Dr. Mariza explains that this is actually a neuroendocrine and metabolic transition driven by changing hormones, brain energy shifts, inflammation, and blood sugar instability.

She breaks down what’s really happening inside the female brain during midlife, why women feel more sensitive to stress, and the most powerful lifestyle strategies to support long-term brain health, energy, mood, and resilience.

If you’ve been wondering why you don’t quite feel like yourself anymore, this episode will help connect the dots—and give you a roadmap forward.

IN THIS EPISODE



Why perimenopause is a neuroendocrine and metabolic brain transition



The connection between estrogen, brain energy, and brain fog



How blood sugar instability worsens anxiety, fatigue, and mood swings



Why inflammation and chronic stress hit harder in midlife



The critical role of sleep, nervous system regulation, and muscle building



The best supplements for brain health, stress resilience, and energy support



Why tracking biomarkers and HRV can help protect long-term brain health

QUOTES

“Stabilizing your blood sugar is the fastest way to reclaim your energy, your focus, and your calm.”

“What we’re dealing with is an energy problem—and once you see it that way, everything changes.”

“Your brain is not broken. It is adapting and recalibrating.”

RESOURCES MENTIONED

Order my new book: The Perimenopause Revolution

https://peri-revolution.com/

Learn more about Joi & Blokes 

https://joiandblokes.com/labs-with-dr-mariza-snyder/

Explore Berkeley Life Nitric Oxide Support

https://berkeleylife.pxf.io/Vxvdja

Download the Midlife Lab Guide

https://dmdl.s3.amazonaws.com/Dr-Mariza_Hormone-Lab-Testing-Checklist-%26-Reference-Guide.pdf

RELATED EPISODES 

728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It

743: Why Your Heart Risk Changes in Menopause with Dr. Jayne Morgan

693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell

717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

“Why is heart disease still the #1 killer of women—and why aren’t we talking about it?”

In this episode, Dr. Mariza sits down with Jayne Morgan to unpack the overlooked connection between perimenopause, menopause, and cardiovascular risk.

Most women are told menopause is just about hormones and symptoms—but it’s actually a vascular transition that directly impacts your heart, blood vessels, and long-term health.

Together, they break down why women are often misdiagnosed, why key risk markers are missed, and what you can do to advocate for yourself early—before a major event happens.

If you’re in your 40s or beyond, this conversation could change how you think about your health—and your future.

Be sure to tune in!

DR. JAYNE MORGAN

Dr. Jayne Morgan is a leading cardiologist and national voice in women’s cardiovascular health. She is passionate about redefining “preventive care” for women—shifting the focus from reproductive health alone to include heart health, vascular function, and long-term longevity.

IN THIS EPISODE

Why heart disease is still the #1 killer of women—and widely overlooked

How perimenopause and menopause impact vascular health

Why women are often misdiagnosed in cardiac and stroke events

The critical labs every woman should be asking for (including Lp(a))

How inflammation, stress, and caregiving burden increase risk

Why movement (not just exercise) is essential for longevity

The real role of hormone therapy in protecting heart health

QUOTES“Real preventive medicine for women is preventive cardiovascular medicine.”

“Menopause is not just a hormonal transition—it’s a vascular one.”

“If you don’t measure it, you can’t manage it.”

RESOURCES MENTIONED

Order my newest book: The Perimenopause Revolution

https://peri-revolution.com/

Dr. Jayne Morgan Instagram

Dr. Jayne Morgan Youtube

RELATED EPISODES 

723: Estrogen, Insulin & Heart Disease: Why Your Risk Rises in Midlife

711: Estrogen, Inflammation, and Your Heart Health: What Every Woman Needs to Know with Dr. Sanjay Bhojra

675: Feeling Off After 40? The Surprising Vitality Molecule to Reignite Your Energy, Libido & Confidence with Cathy Eason 

741: Estrogen, Gut Health, and Metabolism with Siobhan Mitchell

In today’s episode, we’re talking about the very real mental energy drain that so many midlife women are experiencing—and how it can quietly lead to career burnout. 

From mood swings, irritation, and resentment to brain fog and forgetfulness in high-stakes moments, these changes can leave you feeling like you’re not yourself anymore. 

But here’s the truth: this is not a willpower problem or a personal failure— it’s a biological shift happening during perimenopause with very real professional consequences. 

This episode is a call to stop suffering in silence and start advocating for better support, awareness, and care for women in this phase of life. 

If you’re ready to reclaim your clarity and confidence— and step fully into your most powerful chapter—this conversation is for you.

Tune in here!

IN THIS EPISODE

The neuroendocrine transition happening in perimenopause 

How to adapt when your brain is functioning less in midlife 

Different hormone changes and what they mean for your body 

Understanding your biology and supporting your brain in midlife 

Why strategic lifestyle changes matter the most right now 

How to get my top recommendations for battling brain fog from my new book, The Perimenopause Revolution

QUOTES

“That brilliant brain of yours is suddenly running on 25% to 30% less energy because that’s what's going on in perimenopause.”

“65% to 99% of women say their symptoms negatively affected their work performance, with brain fog being the biggest culprit in terms of focus, clarity, alertness, and mental bandwidth. More than half of women make career-limiting decisions during perimenopause.”

“It's about you going through a profound biological transition in your life that deserves support, understanding, and solutions that actually work.”

RESOURCES MENTIONED

Join my Midlife on Fire Collective HERE!

Order my newest book: The Perimenopause Revolution HERE!

RELATED EPISODES 

728: WHY BRAIN FOG ISN’T RANDOM: THE HORMONE SHIFT BEHIND IT

721: No, It’s Not All in Your Head: The Medical Truth About Perimenopause with Dr. Jila Senemar

717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

690: The Perimenopause Revolution: Why midlife isn’t the end — it’s the beginning of your most energized, powerful, and vibrant self

“Why does your body stop responding… even when you’re doing everything right?”

In this episode, Dr. Mariza sits down with Siobhan Mitchell to unpack the true metabolic and cellular shifts happening in perimenopause and menopause.

So many women feel like their body has suddenly turned against them—weight gain, fatigue, brain fog, and rising inflammation—despite doing all the right things. But this isn’t a failure of effort. It’s a biological inflection point driven by declining estrogen and its impact on metabolism, mitochondria, and vascular health.

Together, they break down how estrogen loss reshapes everything from blood sugar control to fat storage, mitochondrial function, and long-term cardiovascular risk—while also exploring the emerging role of gut health and phytoestrogens like S-equol as targeted support.

If you’ve been working harder than ever with fewer results, this episode will help you understand why—and what to do instead.

Be sure to tune in!

SIOBHAN MITCHEL

Dr. Siobhan Mitchel, PhD, is a neuroscientist and Chief Scientific Officer at MitoQ. Her work focuses on mitochondrial health, cellular energy, and the role of oxidative stress in aging—particularly in women navigating perimenopause and menopause. She is passionate about advancing research that supports women’s long-term health, metabolism, and resilience at the cellular level.

IN THIS EPISODE


Why your body stops responding the same way in perimenopause


How estrogen loss impacts metabolism, fat storage, and blood sugar


The role of mitochondria in energy, brain function, and weight changes


Why visceral belly fat increases—and why it’s more dangerous


The connection between gut health, estrogen metabolism, and inflammation


How phytoestrogens (like S-equol) support metabolism and hormone signaling


Why midlife is a metabolic and vascular inflection point—not just hormonal

QUOTES

“This isn’t a failure of effort—it’s a biological shift happening beneath the surface.”

“When estrogen declines, you don’t just lose hormones—you lose metabolic protection.”

“If you support your mitochondria, you support your energy, your metabolism, and your long-term health.”

RESOURCES MENTIONED

Order my new book: The Perimenopause Revolution HERE!

https://peri-revolution.com/

Use code ENERGIZED and get 10% off MitoQ

http://www.mitoq.com/energized

MitoQ Instagram

MitoQ Facebook

MitoQ Youtube

RELATED EPISODES 

693: The Cellular Shift in Perimenopause: Mitochondria, Metabolism, and Energy

728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It

717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause

705: The Metabolic Shift No One Warned You About in Midlife