The Mind-Gut Conversation

• The Exciting Future of Probiotics in Treating Chronic Disease with Deanna Gibson, PhD | MGC Ep. 91

  Inflammatory bowel diseases like ulcerative colitis remain among the most difficult chronic conditions to manage — but new science at the intersection of microbiome research and biotechnology may offer hope.In this episode of The Mind-Gut Conversation, I sit down with Dr. Deanna Gibson, microbiome researcher and cofounder of Melius Microbiomics, to explore how genetically engineered microbial medicines could transform the future of IBD treatment — and what it will take for patients and the medical community to embrace them.In this conversation, we explore:· How Dr. Gibson’s research led to the development of BioPersist™ and BioColonize™ for IBD.· Why new microbiome-targeted therapies are urgently needed — especially for younger patients in whom ulcerative colitis is on the rise.· What makes BioPersist™ different from traditional probiotics and current IBD treatments.· How genetically engineered microbial medicines (GEMMs) represent a new generation of gut therapies.· Early research findings that support BioPersist™ as a promising treatment for ulcerative colitis.· Challenges in gaining public trust for novel biotech therapies amid growing skepticism.· Exciting new discoveries in microbiome science — and the future potential for live biotherapeutics beyond IBD.If you’re curious about the exciting direction where gut health research is headed — and how the microbiome may change the way we treat chronic disease — this episode is for you.Tune in and join the conversation!Disclaimer: Dr. Mayer is the Chief Medical Officer of Melius Microbiomics and has been involved in the commercial development of Genetically Engineered Microbial Medicines (GEMMs).

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• IBS & The Brain-Gut Connection with Emeran Mayer, MD & Dylan Mayer, MS | MGC Ep. 90

  Despite how common IBS is, it remains one of the most misunderstood and misdiagnosed conditions affecting the gut. Whether you’ve been diagnosed with IBS, suspect you might have it or are just curious about the brain-gut connection, this episode is for you.In this episode of The Mind-Gut Conversation, I sit down with my son, Dylan, to tackle some of the most frequently asked questions about IBS — from why gut health is trending to why IBS remains so difficult to treat. It’s an open, honest and evidence-based conversation that brings clarity to a topic that affects millions.In this conversation, we explore:- Why gut health has become such a hot topic — and what that has to do with IBS.- Why the prevalence of IBS hasn’t changed, despite skyrocketing interest in digestive health.- The limits of current diagnostic criteria and what symptoms are being missed.- How IBS fits into a larger picture of brain-gut dysregulation, including anxiety, fatigue and poor sleep.- Whether IBS causes anxiety, or anxiety causes IBS — and what the science says about this “chicken and egg” dilemma.- Why we still don’t have an effective drug treatment for IBS, and what to consider instead.In honor of April being IBS Awareness Month, my in-depth IBS course is 70% off through the end of the month. If you want to go beyond the basics and learn actionable strategies backed by the latest science, you’ll find everything you need at emeranmayer.com.Whether you’re managing symptoms or supporting someone who is, we hope this episode gives you a new perspective on IBS — and a sense of empowerment.Tune in now and join the conversation! We hope you enjoy.Chapters:Introduction 0:00 - 1:18What is behind the gut health craze? 1:18 - 3:35Prevalence of IBS 3:35 - 6:28Limitations of current diagnosis criteria 6:28 - 9:16Anxiety & The Brain-Gut System 9:16 - 15:52Why are there no effective drug treatments for IBS? 15:52 - 18:55Leaving it on a positive note 18:55 - 21:03IBS Resources & Thank You 21:03 - 21:36

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• The Current Science Behind Probiotics with Zain Kassam, MD, MPH | MGC Ep. 89

  Are probiotics really the key to unlocking better gut health? Or are they just another overhyped wellness trend? These are some of the most common questions I get after giving a talk or meeting with a patient.In this episode of The Mind-Gut Conversation, I sit downwith Dr. Zain Kassam, Chief Medical Officer at Seed Health and a pioneer in the field of microbiome therapeutics. If you’ve ever been curious about how probiotics work, how to choose a high-quality supplement, or whether they actually do more than your diet already provides—this is the episode you’ve been waiting for.In this conversation, we explore:• Why the probiotic market is booming—and how Seed Health is setting a new scientific standard.• The critical differences between synbiotics, probiotics and naturally fermented foods.• Are most probiotics backed by real science, or is the supplement industry skipping clinical rigor?• Can probiotics actually go beyond a healthy diet to offer additional health benefits?• How to navigate the sea of probiotic options: what to look for, what to avoid and what actually matters.Dr. Kassam brings a rare blend of scientific depth and real-world experience. He received his MPH from Harvard, completed post-doctoral training at MIT, and has co-founded two foundational microbiome companies—OpenBiome and Finch Therapeutics—before joining Seed. His work has redefined the role of the microbiome in medicine, from establishing the first public stool bank to exploring bioengineered probiotics for chronic disease.If you’re interested in gut health, skeptical about supplement marketing, or just want to understand what’s real and what’s hype when it comes to probiotics, don’t miss this one. Tune in now and join the conversation!-------This episode is brought to you by Seed. Supporting your gut health is a journey—one that includes diet, exercise and lifestyle.But sometimes, life gets in the way, and we could use a little extra support. That’s why I recommend Seed’s DS-01®—a probiotic with clinically studied strains and a prebiotic that support gut health, immunity, and heart health.Use my code MAYER25 for 25% off your first month of Seed, or visit the link here.Disclaimer: Dr. Mayer is a member of Seed's scientific board.-------Learn more at emeranmayer.com-------Chapters:0:00 - 1:18 Introduction1:18 - 7:43 What makes Seed different?7:43 - 12:25 The current state of microbiome science12:25 - 17:30 The multi-billion dollar probiotic market17:30 - 28:00 The future of probiotics & what research is showing28:00 - 29:38 Advertisement29:38 - 35:14 Why has 'gut health' become so popular?35:14 - 40:03 Do healthy people need to take a probiotic?40:03 - 41:47 When you should take a probiotic41:47 - 43:22 Does DS-01 replace a healthy diet & lifestyle?43:22 - 47:08 Why should someone choose Seed's DS-01 over another company's probiotic47:08 - 49:30 Are more microbes in a probiotic really beneficial?49:30 - 52:04 More context on why Seed is a leader in the space52:04 - 52:33 Ending

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• Things You Need To Know For Better Gut Health with Emeran Mayer, MD & Dylan Mayer, MS | MGC Ep. 88

  Got questions about gut health, diet and the microbiome? In this special Ask Me Anything (AMA) episode of The Mind-Gut Conversation, I answer real questions from our members—covering everything from ADHD and the gut to colonic hydrotherapy, ultra-processed foods and how to fix your microbiome after a night of drinking.Joining me for this episode is my son, Dylan, who has been deeply involved in our work at emeranmayer.com. With his background in nutrition and passion for health, we tackle your biggest concerns, including:- The gut microbiome’s role in ADHD—what does the latest research say?- Can kids be taught to “listen” to their gut?- Histamine intolerance, yogurt fermentation, and probiotics—can too much of a good thing backfire?- Does colonic hydrotherapy harm the microbiome?- The truth about protein powders—do they count as ultraprocessed foods?- How does alcohol impact the gut, and can red wine be beneficial?- The carnivore diet, gluten and fiber—what’s best for gut health?- How to distinguish between gut-related, hormone-related or insulin-related symptoms.If you’re looking for science-backed insights on how to optimize your gut health, avoid common pitfalls and make informed choices about your diet and lifestyle, this AMA is for you!Want to submit your own questions for our next AMA? Join our community at www.emeranmayer.com/membership for exclusive Q&As, live events and in-depth courses.As always, we'd greatly appreciate any feedback in the comments below!We hope you enjoy the episode.-------This episode is brought to you by Seed. Supporting your gut health is a journey—one that includes diet, exercise and lifestyle.But sometimes, life gets in the way, and we could use a little extra support. That’s why I recommend Seed’s DS-01®—a probiotic with clinically studied strains and a prebiotic that support gut health, immunity, and heart health.Use my code MAYER25 for 25% off your first month of Seed, or visit the link here.https://seed.com/daily-synbiotic?utm_source=ambassador&utm_medium=podcast&utm_campaign=emeranmayer&utm_term=25p&promo_code=MAYER25-------Chapters0:00 - 3:11 Introduction3:11 - 9:57 Gut Microbiome & ADHD9:57 - 13:27 How Kids Can Learn To "Listen" To Their Gut13:27 - 18:28 Histamine/Tyramine Reactions from Fermented Foods18:28 - 21:09 Colonic Hydrotherapy & Gut Health21:09 - 24:31 Alcohol & Gut Health24:31 - 26:51 Ultraprocessed Foods & Protein Powders26:51 - 30:47 Thoughts on Gluten30:47 - 32:44 Seed's DS-0132:44 - 36:57 Carnivore Diet & Gut Health36:57 - 39:43 Seasonality & Gut Issues39:43 - 41:24 Relationship Between Gut & Neurodegenerative Diseases41:24 - 43:55 Gut-Related vs. Hormone-Related vs. Insulin-Related Issues43:55 - 46:19 Intestinal Methanogen Overgrowth (IMO)46:19 - 48:55 Estrogen Recycling in The Gut48:55 - 52:35 Top 3 Foods For Gut Health & Number 1 To Reduce52:35 - 53:45 Outro

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• The Truth About Sugar & How it Affects Our Health with Robert Lustig, MD | MGC Ep. 87

  Is sugar really the villain behind the chronic disease epidemic? If you care about your metabolic health, obesity and the hidden dangers of processed food, this episode of The Mind-Gut Conversation is one you can’t miss. My guest is Dr. Robert Lustig, an internationally renowned expert on the role of sugar in disease and the bestselling author of Fat Chance. In this episode, we dig into:- The shocking impact of sugar on your metabolism—fructose vs. glucose, which is worse?- Is the sugar in fruit as harmful as the sugar in processed food?- The truth about ultra-processed foods—what’s really making us sick?- Can we reverse the obesity crisis through lifestyle changes, or are new anti-obesity drugs the answer?- How the food industry has manipulated our biology to crave pleasure instead of true wellbeing.Dr. Lustig is a professor emeritus of Pediatrics, Division of Endocrinology at UCSF, with decades of research on childhood obesity, diabetes and the role of the brain in regulating energy balance. His insights have shaped the global conversation on nutrition and metabolic health, cutting through industry myths and misinformation.If you want to take control of your diet, rethink the way you eat and understand the real science behind sugar’s impact, this episode is for you. Tune in now and let us know what you think!-------This episode is brought to you by Seed. Supporting your gut health is a journey—one that includes diet, exercise and lifestyle.But sometimes, life gets in the way, and we could use a little extra support. That’s why I recommend Seed’s DS-01®—a probiotic with clinically studied strains and a prebiotic that support gut health, immunity, and heart health.Use my code MAYER25 for 25% off your first month of Seed, or click here!

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