Mara Aspinall: Taking Diagnostics From Pitch to Patient
Mara Aspinall has long been a leader in precision medicine, championing diagnostics as vital to better treatments and saving lives. She built Genzyme Genetics into the nation’s top testing business, later acquired by LabCorp for $1 billion, and led Ventana (now Roche Tissue Diagnostics) in pioneering companion diagnostics. As co-founder of BlueStone Venture Partners and partner at Illumina Ventures, she continues shaping the field. She also publishes the Diagnostics Year in Review, serves on multiple boards, and co-founded ASU’s School of Biomedical Diagnostics. This episode explores both her vision for testing and her journey to becoming a transformative leader.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Hosted by Jonathan D. GrinsteinAudio mixed and mastered by David MoselyProduced by Bill Levine Hosted on Acast. See acast.com/privacy for more information.
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David Liu: Performing Chemistry on DNA to Unlock Personalized Gene Editing
David R. Liu, PhD, Harvard and Broad Institute professor, invented base and prime editing—gene editing tools now in 20+ clinical trials with early wins against sickle cell, leukemia, and more. Founder of Editas, Beam, and Prime Medicine, and winner of the 2025 Breakthrough Prize, Liu joins Behind The Breakthroughs to share how chemistry and evolution are driving the next wave of medicine.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Hosted by Jonathan D. GrinsteinAudio mixed and mastered by David MoselyProduced by Bill Levine Hosted on Acast. See acast.com/privacy for more information.
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Janice Chen: Unleashing CRISPR’s Clinical and Diagnostic Potential
Janice Chen, PhD, helped transform CRISPR from a lab discovery into a life-saving tool. As co-founder of Mammoth Biosciences with Jennifer Doudna, Trevor Martin, and Lucas Harrington, she’s driven efforts to harness CRISPR for human health and diagnostics. On Behind the Breakthroughs, Chen shares how she’s turning a once-theoretical gene editor into a medical revolution.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Hosted by Jonathan D. GrinsteinAudio mixed and mastered by David MoselyProduced by Bill Levine Hosted on Acast. See acast.com/privacy for more information.
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Amber Salzman: Epigenetic Editing Aims to Refine Personalized Genetic Medicine
With recent safety setbacks in gene therapy underscoring the risks of genetic medicine, Amber Salzman, PhD, is charting a different course. After 25 years in big pharma, she now leads Epicrispr, where their Gene Expression Modulation System (GEMS) fine-tunes gene activity to tackle diseases too complex for traditional gene replacement, including Duchenne muscular dystrophy. On Behind the Breakthroughs, Salzman shares how epigenomic modulation could open new frontiers in treatment.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Hosted by Jonathan D. GrinsteinProduced by Bill LevineAudio mixed and mastered by David MoselyMusic provided by penguinmusic Hosted on Acast. See acast.com/privacy for more information.
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Mike Previte: Predicting Biology with Spatiotemporal Multiomics
Think Good Will Hunting—but in biology. Mike Previte, PhD, once at Illumina and now CTO and co-founder of Element Biosciences, is building tools to move beyond DNA and RNA sequencing toward a true 5D view of life. On Behind the Breakthroughs, he explains how technologies like AVITI 24 could unlock predictive precision medicine by revealing how cells behave across time and space.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Hosted by Jonathan D. GrinsteinProduced by Bill LevineAudio mixed and mastered by David MoselyMusic provided by penguinmusic Hosted on Acast. See acast.com/privacy for more information.
Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care.In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire and inform you about personalized medicine's future. Hosted on Acast. See acast.com/privacy for more information.
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