1139 episodios
“Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141
24/08/2026 | 2 h 5 minDr David Sinclair is a geneticist, professor at Harvard Medical School, and author.
Can human aging actually be reversed? What happens if we treat aging as a disease rather than an inevitability? And how close are scientists to turning age-reversal experiments into medicines that could radically extend our lives?
Expect to learn how scientists can reset the age of cells without causing cancer, whether resveratrol and NAD supplements actually work, why three meals a day plus snacks might be marketing, the best exercise protocol for longevity, whether GLP-1s are legitimate longevity drugs, and much more...
Sponsors:
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Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com
Timestamps:
(0:00) How David’s Work Has Evolved(0:58) Can Scientists Actually Reverse Blindness?(5:53) How Does ER100 Work?(8:57) Is Aging a Disease?(10:14) What’s Next in Age Reversal?(14:00) How to Reverse Aging Without Going Too Far(17:10) What Most Longevity Experts Secretly Believe(20:48) The Biggest Levers for Reversing Aging(22:53) Can We Survive 2 Weeks Without Food?(32:55) The Most Effective Way to Fast(36:10) Does Calorie Restriction Actually Extend Human Life?(40:52) Is the Proteinmaxxing Movement Overhyped?(44:41) Could Sex Help You Live Longer?(47:57) Why Quality Sleep Is Essential for Longevity(51:01) Can Overthinking Shorten Your Lifespan?(55:05) What Longevity Drugs Does David Take Every Day?(56:48) The Truth Behind Controversial Longevity Drugs(1:13:51) Can Erectile Dysfunction Medication Treat Cancer?(1:17:46) The Hidden Danger of Heavy Metals in Supplements(1:21:45) The Benefits of Creating a Longevity Community(1:24:54) Sauna vs Cold Plunges: Which Is Better for Longevity?(1:31:34) Is Bryan Johnson’s Protocol Actually Working?(1:35:39) Are Vitamins a Waste of Money?(1:39:41) Could GLP-1s Protect Against Dementia?(1:46:23) What’s AI Doing to Longevity Research?(1:54:30) Can Your Mindset Affect How Long You Live?(1:56:55) The Two Things That Matter Most for Longevity(1:58:01) Which Longevity Methods Actually Work?(2:03:31) When Health Optimisation Goes Too Far(2:05:18) Where to Find David
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
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Get In Touch:
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Learn more about your ad choices. Visit megaphone.fm/adchoices- Johnny Chang is a former gang member and inmate turned Christian pastor, speaker, and podcaster.
What happens when a boy enters prison at 12 and doesn’t emerge until 25? That was Johnny Chang’s reality. Raised amid violence and gangs, he eventually found God. But does a violent past define a man forever, or can he choose to become someone better?
Expect to learn how Johnny was brought into gang life when he was 12 years old, why Juvie is more violent but less lethal than prison, what life is like in prison and what it takes to survive, the hardest things to unlearn after prison, how Johnny found god and started preaching the gospel, what twelve-year-old Johnny would think if he could see himself now and much more…
Sponsors:
See discounts for all the products I use and recommend: https://chriswillx.com/deals
Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom
Get a Free Sample Pack of LMNT’s most popular flavours with your first purchase at https://drinklmnt.com/modernwisdom
Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom
Get 15% off your first order of my favourite Non-Alcoholic Brew at https://athleticbrewing.com/modernwisdom
Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com
Timestamps:
(00:00) How Johnny Got Pulled Into Gang Life
(08:44) Surviving California’s Youth Prison System
(16:08) How Prison Politics Reshapes Gang Mentality
(20:43) The Hidden Status Hierarchy Inside Prison
(22:54) Why Prison Violence Is So Manipulative
(29:26) Johnny’s Most Dangerous Moment Behind Bars
(33:57) The Prison Habits That Are Hardest to Unlearn
(39:04) Why Life After Prison Is So Difficult to Rebuild
(43:01) Why Johnny Feared Life Outside Prison
(57:04) How Johnny Found Purpose Through Christianity
(01:11:41) The Courage of Forgiveness
(01:16:26) Why Finding Peace Can Feel Like a Battle
(01:21:19) How Do We Distinguish God’s Voice From Our Own?
(01:25:04) Is Turning to Religion a Sign of Weakness?
(01:27:25) Why Are Vulnerable Conversations So Hard?
(01:29:59) Is Forgiveness Actually Selfish?
(01:41:51) Why Returning to Prison Terrified Johnny
(01:52:51) What Would Johnny’s 12-Year-Old Self Think Now?
(01:59:01) Where to Find Johnny
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
-
Get In Touch:
Instagram: https://www.instagram.com/chriswillx
Twitter: https://www.twitter.com/chriswillx
YouTube: https://www.youtube.com/modernwisdompodcast
Email: https://chriswillx.com/contact
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Learn more about your ad choices. Visit megaphone.fm/adchoices - In the third episode of Mostly Wise, we explore:
If Matt and Jeff could survive Navy SEAL selection, training and hazing.
Whether the Navy actually has trained animals like killer assassin kamikaze dolphins.
How the guys deal with their own versions of sobriety.
Why Love on The Spectrum is potentially problematic.
What it was like for Jocko to be in the Military on 9/11.
The story of the gun no manufacturer dared to make after testing it.
And much more...
Guests
Jocko Willink is a retired United States Navy officer in SEAL Team 3, an author and a podcaster.
Matt McCusker is a comedian, writer, author and podcaster.
Jeff Dye is a comedian, actor, television host and podcaster.
Sponsors:
See discounts for all the products I use and recommend: https://chriswillx.com/deals
Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom
Get up to $350 off the Eight Sleep Pod 5 at https://eightsleep.com/modernwisdom
Get a free bottle of D3K2, an AG1 Welcome Kit, and more when you first subscribe at https://ag1.info/modernwisdom
Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom
Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com
Timestamps:
(00:00) Can You Be Openly Gay in the Military?
(02:26) Are Women’s Sports as Good as Men’s?
(08:19) What It Really Takes to Become a Navy SEAL
(20:17) The Most Uncontrollable Navy SEALs
(24:35) Do Dolphins Work for the Navy SEALs?
(37:08) Could You Run a Marathon in Wheelies?
(38:34) Is Climbing Everest a Good Idea?
(44:32) The Privacy Problem With High-Rise Living
(51:14) How Embarrassment Pushed Jeff Into Sobriety
(01:01:12) Why Men Can’t Win During Labour
(01:05:32) Why Jocko Didn’t Have a Batchelor Party
(01:07:39) Is Sober Dating Like Love on the Spectrum?
(01:17:47) Do Single Guys Go Crazy After 7pm?
(01:23:00) Why Social Dating Is Too Complicated
(01:30:27) Are Women Trying to Reset Their Body Count?
(01:34:22) Why Weed Affects Everyone Differently
(01:46:23) Why a 25mm Sniper Rifle Should Never Exist
(01:52:46) The Best Perks of Being a Veteran
(01:58:31) The Reality of Waking Up to the Iraq War
(02:01:07) How 9/11 Changed the World Forever
(02:10:00) Why War Never Goes to Plan
(02:12:48) How the Russia/Ukraine Conflict Changed Modern Warfare
(02:20:27) Is the Military Already Enhancing Soldiers?
(02:27:40) Would Veterans Do One More Tour?
(02:31:59) Where to Find the Guys
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
-
Get In Touch:
Instagram: https://www.instagram.com/chriswillx
Twitter: https://www.twitter.com/chriswillx
YouTube: https://www.youtube.com/modernwisdompodcast
Email: https://chriswillx.com/contact
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Learn more about your ad choices. Visit megaphone.fm/adchoices - In this AI debate, we explore:
Whether humans will exist in 2040.
What will happen once we reach AGI.
Whether AI gets smart enough to act malevolently or benevolently towards humans.
If AI will grow powerful enough to be out of human control.
and much more...
Guests
Zack Kass is an AI futurist, advisor, speaker, and author.
Liv Boeree is a physicist, science communicator, podcaster and former professional poker champion.
Aric Floyd is an AI writer, and video producer.
Sponsors:
See discounts for all the products I use and recommend: https://chriswillx.com/deals
Timestamps:
(00:00) Will Humans Still Be Around in 2040?
(08:20) What Jobs Will Be Protected From AI?
(14:22) Finding Meaning in a Post-Work World
(23:13) Technology Is Pulling Us From Our Purpose
(27:12) Where Do We Draw the Line With Outsourcing Thinking?
(39:58) Is AI Unlocking Human Potential?
(42:28) Refusal or Obedience: What’s More Dangerous?
(46:01) The AI Attack That Should Worry Everyone
(54:44) Should We Slow Down Advanced AI?
(56:41) Does Recursive Research Actually Work?
(01:10:52) How Safe Is AI?
(01:14:01) Can We Reach a Peace Deal for a Superintelligent World?
(01:22:38) Why AI 2040 Got So Much Right
(01:26:21) Is AGI Inevitable?
(01:30:39) Could Techno-Pastoralism Be the Future?
(01:37:16) Is AI Replacing Human Connection?
(01:45:36) How Do We Navigate the Purpose-Friction Problem?
(02:00:50) Why Data Centre Policy Matters More Than Ever
(02:05:56) The Concentration of Power Concern
(02:11:39) Is the Frontier Strategy the Winning Condition?
(02:18:17) Will AI Weaken Democracy?
(02:29:11) How We Can Limit the Concentration of Power
(02:31:45) Is ChatGPT Pessimistic About the Future?
(02:37:54) What Should We Be Focused On?
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
-
Get In Touch:
Instagram: https://www.instagram.com/chriswillx
Twitter: https://www.twitter.com/chriswillx
YouTube: https://www.youtube.com/modernwisdompodcast
Email: https://chriswillx.com/contact
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Learn more about your ad choices. Visit megaphone.fm/adchoices Harvard Professor: “I Tried Every Diet. This Is By Far The Worst.” - Daniel Lieberman - #1137
15/08/2026 | 2 h 8 minDaniel Lieberman is a Harvard professor of human evolutionary biology, paleoanthropologist, and author.
What is the best diet for peak human health? From vegan and carnivore to Mediterranean and raw food, how do you know which approach is right for you? And are diet and exercise still the keys to good health—or does modern science offer another solution?
Expect to learn why nutrition and diet feel much like a religion, which diet is healthier: Vegan or Carnivore, why the Blue Zone science might be one big scam, what the best and worst diets are for your health, why most diets stop working after a certain period, if GLP-1s are the artificial solution to a real problem and much more…
Sponsors:
See discounts for all the products I use and recommend: https://chriswillx.com/deals
Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom
Sign up for a free trial from Shopify at https://shopify.com/modernwisdom
Get up to $50 off the RP Hypertrophy App at https://rpstrength.com/modernwisdom
Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom
Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com
Timestamps:
(00:00) How Diet Shapes the Way You Think About Food
(02:12) Diet Through the Lens of Human Evolution
(02:55) Do We Look for Meaning Through Diet?
(05:56) Are Plant-Based Diets Actually Better?
(11:30) Why the Carnivore Diet Is Taking Off
(14:04) The Truth About Proteinmaxxing
(19:50) Is There Really One “Best” Diet?
(24:00) Can We Trust Epidemiological Studies?
(31:46) Why the Mediterranean Diet Keeps Winning
(34:36) The Blue Zones Myth Explained
(42:18) Can You Lose Weight Without Cutting Carbs?
(51:57) Why Dieting Is Simpler Than You Think
(54:00) Is Calorie Restriction Worth It?
(01:02:35) What’s Special About Intermittent Fasting?
(01:06:15) Breaking Down the Paleo Diet
(01:11:13) The Truth About Antinutrients
(01:12:45) Why the Raw Food Diet Is So Hard
(01:15:48) What Cooking Really Does to Digestion
(01:19:38) Did Farming Make Humans Healthier?
(01:24:58) What’s the Real Story With Gluten?
(01:27:51) Why Are So Many People Overweight?
(01:32:16) Why We Crave Balanced Flavours
(01:38:41) Food Labels Don’t Tell the Whole Story
(01:43:06) “Healthy” Foods That Could Be Making You Worse
(01:51:40) Do Diets Stop Working Eventually?
(01:54:08) The Biggest Concerns About GLP-1s
(01:59:40) The Principles Behind Every Healthy Diet
(02:07:35) Where to Find Daniel
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
-
Get In Touch:
Instagram: https://www.instagram.com/chriswillx
Twitter: https://www.twitter.com/chriswillx
YouTube: https://www.youtube.com/modernwisdompodcast
Email: https://chriswillx.com/contact
-
Learn more about your ad choices. Visit megaphone.fm/adchoices
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