226 episodios
October 2026: The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions
01/10/2026 | 25 minDr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics.
00:42 Conway interview
02:34 Quality of life
05:13 Ethical considerations of a sham arm in this population
07:00 Timing and VNS treatment
08:03 Clinical implications
09:02 Limitations
10:12 Further research
11:30 McDonald and Kalin interview
13:50 Song et al.
14:08 Li et al.
15:44 Donnery et al.
16:38 Valiengo et al.
17:28 Rush
20:03 Mahmoudi
22:37 Conway et al.
Transcript
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E-mail us at ajp@psych.orgSeptember 2026: Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial
01/09/2026 | 29 minDr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood episodes. Afterwards, Dr. Ned Kalin will join us again to discuss the rest of the September issue of the Journal, which takes a close look at clinical treatment.
00:44 Findings
01:42 How the app works
03:05 Differences between the app and traditional lifestyle advice
04:14 Ethics surrounding shame treatment arms
05:43 Broader applicability of the intervention
06:50 Limitations
08:19 Immediate clinical implications
09:33 Further research
10:08 Kalin interview
10:27 Yeom et al.
16:02 Schacht et al.
20:31 Khosravani et al.
24:52 Peterson et al.
Transcript
Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.
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E-mail us at ajp@psych.org81: Psychiatric Risk Associated With Large Language Model Chatbots: An Emerging Concern
15/08/2026 | 26 minAmandeep Jutla, M.D., joins Dr. Dixon and Dr. Berezin, with guest host Dr. Matt Hirschtritt, to discuss concerns surrounding the use of large language model chatbots and psychiatric risk.
01:08 Introduction
04:03 Language models in 2019
05:18 The appeal of chat-based AI for autistic adults
07:34 Do you use chat-based AI models personally?
09:44 Specific concerns of interacting with AI chat bots
11:07 The illusion of speaking with a person
13:34 Suggestions for clinicians and researchers
16:17 Questions a clinician should ask
18:29 Uses for AI models
20:11 Can chat bots get good at providing advice?
21:30 Regulations?
24:12 Motivational interviewing
Transcript
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Check out Editor's Choice, a set of curated collections from the rich resource of articles published in the journal. Sign up to receive notification of new Editor's Choice collections.
Browse other articles on our website.
Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it.
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E-mail us at psjournal@psych.orgAugust 2026: Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
01/08/2026 | 33 minDr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure and one without. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the August issue of the Journal, which takes a look at issues surrounding schizophrenia spectrum disorder, from the clinical to basic science.
00:40 D'Souza interview
02:38 Subtyping and schizophrenia spectrum disorder
04:19 Relapse and long-term implications for cannabis induced psychosis
05:43 Improvements in cognition
08:03 Differences between the groups
09:26 Greater access and greater potency of cannabis products
11:29 Further research
13:45 Kalin interview
13:59 D'Souza et al.
21:34 Forsyth et al.
27:36 Enwright et al.
Transcript
Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.
Subscribe to the podcast here.
Listen to other podcasts produced by the American Psychiatric Association.
Browse articles online.
How authors may submit their work.
Follow the journals of APA Publishing on Twitter.
E-mail us at ajp@psych.orgJuly 2026: Social Determinants of Health in Psychiatric Disorders: Exciting Opportunities for Biopsychosocial Research and Clinical Care
01/07/2026 | 37 minDr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin once again puts the rest of the July issue into context.
00:31 Impacts of social determinants of health on psychiatric disorders, research, and clinical care
04:43 Health related social needs versus social determinants of health
08:47 Loneliness as a risk factor
12:36 A clinician's role in societal factors
14:47 Mechanistic understandings social determinants and the exposome
18:17 Further research
22:25 Kalin interview
22:30 Jeste and Gyan
23:33 Blundell et al.
28:03 Yang et al.
32:20 Van der Meer et al.
Transcript
Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.
Subscribe to the podcast here.
Listen to other podcasts produced by the American Psychiatric Association.
Browse articles online.
How authors may submit their work.
Follow the journals of APA Publishing on Twitter.
E-mail us at ajp@psych.org
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Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month's issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.
This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.
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