The Immunology Podcast

Guest:

Dr. Sharon Lewin is the Director of the Peter Doherty Institute for Infection and Immunity, where her team studies HIV. She talks about the current landscape in HIV research and treatments, and how new therapies could target latent viral reservoirs.

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The Immunology Science Round Up

Immunosurveillance in the Skin: A neuro-epithelial axis can tune regional immunosurveillance against melanoma.

B Cells in Aging: B cells contributed to the age-related reduction of naive CD4 T cells.

The Gut–Brain Axis in Parkinson’s: Muscularis macrophages, housekeepers of intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease.

How IL-2 Signaling Regulates Inflammation: IL-2 signaling promotes the generation of IL-10pos age-associated B cells, with implications for autoimmunity and inflammation.

Image courtesy of Dr. Sharon Lewin









































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Guest:

Dr. Rafi Ahmed is a Professor in the Department of Microbiology and Immunology and the Director of the Emory Vaccine Center at Emory University. He talks about his early work on memory T cells and its applications in autoimmune diseases and cancer.

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The Immunology Round Up

CAR T Therapy for Hemolytic Anemia: CD19 CAR T cells resulted in sustained remission in patients with multirefractory autoimmune hemolytic anemia. (3:05)

How Epstein-Barr Virus and Genetics Drive Multiple Sclerosis: A new study provides a new mechanistic link for how the environmental and genetic risk factors may contribute jointly to multiple sclerosis. (8:30)

Autoantigens in Multiple Sclerosis: EBNA1 CD4+ T cells can target the multiple sclerosis autoantigen anoctamin-2, establishing a link between Epstein-Barr infection and neuroinflammation. (18:45)

Microbiota-Induced T Cell Plasticity: Molecular mimicry between a gut commensal and a tumor antigen can boost the efficacy of immune checkpoint blockade therapy and restrain tumor growth. (26:00)









































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Guests:

Dr. Ulrich von Andrian is the Mallinckrodt Professor of Immunopathology at Harvard Medical School and President of the American Association of Immunologists (AAI). Dr. Shekhar Pasare is Professor and Director of the Division of Immunobiology at Cincinnati Children’s Hospital Medical Center. He is also the Program Committee Chair for the AAI’s annual meetings. They discuss the upcoming IMMUNOLOGY2026 meeting taking place April 15-19 in Boston. They cover highlights of the program including the Presidential Symposium, special sessions, and opportunities for trainees. (42:30)

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Wallchart: T Cell Nomenclature: From Subsets to Modules

The Immunology Science Round Up

Psoriatic Arthritis –  A two-step process involving skin-derived myeloid precursors and joint-resident fibroblasts orchestrates the spread of inflammation from the skin to the joints. (6:15)

Chemotherapy and Cardiac-Resident Macrophages – DNA-damaging chemotherapy can reshape cardiac macrophage ontogeny. (13:50)

Dendritic Cell Cross-Presentation – Neoantigen cross-presentation by Type 1 conventional dendritic cells can determine the immune visibility of the tumor mutational landscape. (26:00)

T Cell Cross-Reactivity – Co-receptor switching generates super selective T cells that reduce the risk of lethal off-target cross-reactivity. (32:20)

Images courtesy of Drs. Ulrich von Andrian and Shekhar Pasare









































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Guest:

Dr. Jayne Danska is a Senior Scientist, Genetics and Genome Biology at the Hospital for Sick Children Research Institute. She is also Associate Chief of Research, Faculty Development and Diversity, and Professor at the University of Toronto. Her research focuses on the microbiome in type 1 diabetes. She discusses insights from longitudinal human studies and mouse models. (40:00)

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Wallchart: T Cell Nomenclature: From Subsets to Modules

The Immunology Round Up

Vaccination for Anaphylaxis –  A vaccine against IgE protected against anaphylaxis in a mouse model. (2:53)

How RSV Can Lead to Asthma – Researchers identified maternal allergy and neonatal RSV infection as converging Fc receptor-dependent risk factors for asthma. (9:50)

Antigen Presentation for MAIT Cell Immunity – Macrophages are key for MR1 antigen presentation and MAIT cell immunity. (20:30)

HIV Remission after Stem Cell Transplantation – After an allogeneic stem cell transplant, a patient discontinued antiretroviral therapy and sustained HIV remission for over six years. (27:00)









































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Guest:

Dr. Ana Anderson is currently the Albert H. Coons Professor of Neurology at Harvard Medical School, Senior Scientist at the Brigham and Women’s Hospital, Institute Member of the Broad Institute of MIT and Harvard, and Core Faculty Member of the Gene Lay Institute of Immunology and Inflammation. She talks about her research on immune regulation in cancer and enhancing anti-tumor immunity. (38:33)

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Download a free wallchart on the production of CAR T cells.

The Immunology Round Up

CAR Tregs for Atherosclerosis: Anti-oxidized low-density lipoprotein CAR Tregs reduce atherosclerotic plaque formation in mouse models. (2:20)

Tumor-Reactive T Cells: Tumor-reactive CD8+ T cells can be isolated and expanded from clinical samples. (14:24)

Harnessing Myeloid and Lymphoid Synergy for Immunotherapy: Myeloid-targeted immunocytokines and natural killer/T cell enhancers show potential for treating solid cancers. (18:50)

Subcutaneous Fat Affects Intestinal Aging: Subcutaneous white adipose tissue dysfunction triggers aging-like intestinal dysfunctions in mouse models. (32:40)









































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