Shirtloads of Science

***Prof Lucas would like to provide the following clarification in regards to comments relating to prenatal BPA exposure and male autism spectrum disorder: "A positive association between high prenatal BPA exposure and ASD diagnosis was only seen in male offspring with a genetic predisposition to low aromatase enzyme activity."

Professor Michaela Lucas, an Immunologist and Immunopathologist researching the health impacts of plastics, joins me to explore what microplastics and plastic-associated chemicals may be doing inside our bodies. We discuss how compounds like bisphenols and phthalates can act like hormone-mimicking molecules, the evidence linking plastic exposure to developmental and fertility concerns, and why some estimates of microplastics in the body may have been overstated.

Professor Lucas also shares insights from her ongoing study in Perth examining how everyday exposures, particularly ultra-processed foods packaged in plastic, may contribute to microplastics in the body. Listeners can subscribe to receive the study results when they're released via www.uwa.edu.au/projects/the-perth-trial.
Linkedin: @prof-michaela-lucas/

I'm joined by Dr. Anna Broinowski - Senior Lecturer and Director of the Master of Film and Screen Arts at Sydney College of the Arts, University of Sydney - to unpack the rise of deepfakes and synthetic media.
We discuss the emergence of deepfake pornography in 2017, the fact that around 90% of deepfake content targets women and girls, and the growing use of AI in propaganda. From political manipulation to fake ads impersonating me (!), this episode explores how deepfakes are eroding trust, and what that means for the future of media, filmmaking and truth more broadly.

Nitrous oxide (better known as "laughing gas") is widely used in medicine as a safe anaesthetic and pain reliever. It's also found in whipped cream canisters and even used in car engines. But Angela Chiew, toxicologist and Associate Professor at UNSW, joins me to set the record straight: the growing recreational misuse of this easily accessible gas is causing serious long-term harm, including nerve damage, cognitive damage, weakening of the spinal cord and mobility impairments. 

Cases of misuse are rising globally, likely driven by how easy it is to legally purchase the drug in many countries. This episode unpacks the hidden dangers behind a gas many once thought was just a harmless high.

Linkedin: Angela Chiew
X: AngelaChiewA

In the final episode of the Great AI Safety Debrief series with Dr. Petr Lebedev, we discuss job eradication, AI alignment and the rise in cases of AI deceiving humans. Petr unpacks ideas like AI scheming, situation awareness, parasitic relationships between humans and machines, and even the possibility of AI developing belief systems of its own. We end by zooming out to existential risk, Alan Turing's early warnings, and why aligning AI with human values may be one of the most difficult (and urgent) challenges humanity must face.

Linkedin: Petr Lebedev
palisaderesearch.org/

In part two, Dr. Petr Lebedev and I dive deeper into how modern AI systems are grown, not programmed, and the emergence of Shutdown Resistance. We explore AI performance in math and coding competitions, the rapid evolution of ChatGPT models, and why companies are already letting AI write the majority of their code. Petr explains how huge investments globally are pushing these systems forward faster than we can fully understand or control.

The final episode in this 3 part series drops next week!

Linkedin: Petr Lebedev
palisaderesearch.org/