This Week in Neuroscience

Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major histopathological hallmark of Alzheimer's disease.
Hosts: Vincent Racaniello and Tim Cheung
Guest: Melissa Cooper
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Arc and Tau intercellular transmission (Cell)
Timestamps by Jolene Ramsey. Thanks!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv

Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks.
Hosts: Vincent Racaniello and Tim Cheung
Guest: Melissa Cooper
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Astrocytes form plastic networks (Nature)
Newly found brain network (Nature)
Timestamps by Jolene Ramsey. Thanks!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv

TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them.
Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung
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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair (Nature)
Timestamps by Jolene Ramsey. Thanks!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin.
.Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung
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Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits (Cell Host Microbe)
Timestamps by Jolene Ramsey. Thanks!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds.
Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung
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Links for this episode
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Psychedelics rewire the brain from within (Science)
Psychedelics elicit their effects by Gi signaling (Nature)
History of LSD (Wikipedia)
Timestamps by Jolene Ramsey. Thanks!
Music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv