STH - E30 Dr. Kliment Verba - Cryo-EM & COVID-19 virus receptor traps
Dr. Kliment Verba is an Assistant Professor at the Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology at UCSF. Dr. Verba uses biophysical methods such as cryo-EM (cryogenic electron microscopy) to study structural biology and elucidate how proteins look in 3D, down to atomic details. His work spans topics ranging from cancer biology to virology, including recent work on the COVID-19 virus, which we discuss in this episode. For more information, visit Dr. Verba's profile and the QBI website.
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STH - E29 Dr. Derek Lowe - Blogging & Drug Discovery
Dr. Derek Lowe is a medicinal chemist, author, and blogger. He is currently Director in Chemical Biology and Therapeutics at the Novartis Institutes for Biomedical Research (NIBR). Dr. Lowe’s work in drug discovery has spanned multiple decades with tenures at Schering-Plough, Bayer, and Vertex Pharmaceuticals. In addition to his industry work, Dr. Lowe authors a popular blog covering topics in drug discovery; check it out here: In the Pipeline.
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STH - E28 Dr. Eric Wang Returns - Leukemia & Therapy Resistance
Dr. Eric Wang is an Assistant Professor at The Jackson Laboratory (JAX) for Genomic Medicine. Dr. Wang's work has uncovered new therapeutic vulnerabilities in RNA-binding protein networks in leukemia through the use of genomic screening approaches, which we discuss in this episode. His lab investigates therapy resistance in cancer, with a focus on leukemias. For more information, visit his lab page: Wang Lab
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STH - E27 Dr. Mario Suva
Dr. Mario Suva is an Associate Professor of Pathology at Harvard Medical School and Massachusetts General Hospital, is affiliated with the Neuro-Oncology program at Dana-Farber/Harvard Cancer Center, and is a member of the Broad Institute of MIT and Harvard. Dr. Suva's lab focuses on the biology of brain tumors, using single-cell technologies to dissect cellular heterogeneity and plasticity. Furthermore, recent work from his lab describes an atlas of glioma-infiltrating T cells, which we discuss in this episode. For more information, visit his lab page: Suva Lab
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STH - E26 Dr. Mariella G. Filbin
Dr. Mariella G. Filbin is an Attending Physician of Pediatric Oncology at Dana-Farber Cancer Institute, an Assistant Professor of Pediatrics at Harvard Medical School, and an Associate Member of the Broad Institute of Harvard and MIT. The Filbin Lab focuses its efforts on studying pediatric brain tumors, particularly lethal high-grade gliomas, including diffuse intrinsic pontine glioma (DIPG) and malignant embryonal brain tumors. Dr. Filbin's approach to understanding these tumors involves genomic technologies such as single cell RNA sequencing, which we discuss in this episode. For more information, visit her lab page: Filbin Lab
A laid-back conversation with scientists engaged in exciting work. We will discuss their research and explore the path these individuals took in getting to where they are today. My goal is to get to know the human behind the scientist. Join in!
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