Psychopharmacology and Psychiatry Updates

In this episode, we review a JAMA Psychiatry study of over 4 million pregnancies examining first-trimester Z-drug exposure and congenital malformations. Dr. Amanda Koire explains why overall risk wasn't increased, what the neural tube defect signal means, and how to evaluate insomnia before prescribing.
Faculty: Amanda Koire, M.D., Ph.D.
Host: Flavio Guzmán, M.D.
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Earn 0.75 CMEs: Quick Take Vol. 86
Are Z-Drugs Safe in the First Trimester of Pregnancy?

Faculty: Robert Hudak, M.D.
Host: Flavio Guzmán, M.D.
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Earn 1.25 CME: Treatment-Resistant OCD: From SSRIs to Augmentation
Glutamatergic Augmentation in OCD: Memantine, Riluzole, Lamotrigine and Other Agents

Faculty: Oliver Freudenreich, M.D.
Host: Flavio Guzmán, M.D.
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Earn 0.75 CMEs: Quick Take Vol. 85
Schizophrenia: Which of Seven Antipsychotics Wins on Acute Efficacy and Safety?

Faculty: Robert Hudak, M.D.
Host: Flavio Guzmán, M.D.
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Earn 1.25 CME: SSRI Dosing for OCD: Beyond FDA Guidelines
Treatment-Resistant OCD: From SSRIs to Augmentation

In this episode, we explore a new meta-analysis reconciling trazodone's real-world reputation with cautious sleep medicine guidelines, examining its effects on sleep architecture and depressive symptoms in patients with comorbid insomnia and depression, alongside its notable side effect profile. Can a decades-old antidepressant be the missing link for restorative sleep? 
Faculty: Paul Zarkowski, M.D.
Host: Flavio Guzmán, M.D.
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Earn 0.5 CMEs: Quick Take Vol. 85
Trazodone for Insomnia and Comorbid Depression: Are the AASM Guidelines Relevant?