The Human Upgrade: Biohacking for Longevity & Performance

PhenoNet Cleared By FDA To Begin Phase 3 Trial Of Inhaled Alzheimer's Drug
PhenoNet has received FDA clearance to begin a Phase 3 trial of PHENOGENE-1A, an inhaled formulation of cromolyn sodium, an asthma drug with decades of safety data. Unlike most Alzheimer's therapies, which target only APOE4 gene carriers, this ~648-person trial stratifies both carriers and non-carriers by genotype, testing whether reducing amyloid aggregation, inflammation, and microglial dysfunction can benefit a broader Alzheimer's population than current treatments reach. Host Dave Asprey explains why this genotype-inclusive design challenges the field's narrow focus on APOE4 carriers, and what it means for families with Alzheimer's history who don't carry the gene.
Sources:
https://www.morningstar.com/news/business-wire/20260813649121/phenonet-cleared-by-fda-to-begin-phase-3-trial-of-inhaled-phenogene-1a-in-early-alzheimers-disease
https://www.businesswire.com/news/home/20260813649121/en/
https://www.phenonet.us

~~~

University Of Zurich Researchers Discover The Adult Brain Can Repair Itself Better Than Believed
Researchers at the University of Zurich identified a population of "regenerative astrocytes" in living mouse brains that repair damaged tissue through a previously unknown mechanism: dividing cells send newly formed nuclei traveling across long cellular extensions to repopulate injured regions and rebuild the astrocyte network. The discovery overturns the long-standing assumption that adult brains have limited capacity to replace lost astrocytes after injury or autoimmune disease. Host Dave Asprey unpacks why this finding reframes brain injury recovery as something the body may already be equipped to handle, and what the newly identified genetic pathways could mean for future regenerative therapies.
Sources:
https://www.news.uzh.ch/en/articles/media/2026/regenerative-astrocytes.html
https://www.sciencedaily.com/releases/2026/08/260812015158.htm
https://www.eurekalert.org/news-releases/1139114
https://www.nature.com/articles/s41593-026-02354-5

~~~

Sheep's Wool-Derived Keratin Outperforms Collagen In Bone Regeneration Study
Researchers at King's College London developed a keratin scaffold from sheep's wool, a farming industry waste product, and tested it against collagen, the current gold standard, in rats with non-healing skull defects. While collagen produced more total bone volume, the keratin scaffold generated bone that was more structurally organized and closer to natural bone architecture, while remaining stable and integrating cleanly with surrounding tissue. Host Dave Asprey explains why bone quality, not just quantity, matters for weight-bearing repair, and why a cheaper, more sustainable material outperforming the standard is a bigger deal than it sounds.
Sources:
https://medicalxpress.com/news/2026-04-scientists-wool-bone-material.html
https://www.sciencedaily.com/releases/2026/08/260812015210.htm
https://www.ivanhoe.com/news_flash/scientists-turn-sheeps-wool-into-a-material-that-helps-regrow-bone-click-here/

~~~

Oral GLP-1 Pill Aleniglipron Shows 12% Weight Loss In Phase 2b Trial
Structure Therapeutics' oral small-molecule GLP-1 receptor agonist, aleniglipron, produced up to 12.1% weight loss at 36 weeks in a 230-person Phase 2b trial, with no apparent plateau and continued loss to 16% in the open-label extension, putting an oral pill in the same efficacy range as injectable GLP-1 drugs like Wegovy and Ozempic. Host Dave Asprey weighs the compliance advantage of an oral option against his ongoing concerns about muscle loss, rebound weight gain, and the fact that GLP-1 drugs treat a symptom rather than the underlying metabolic cause.
Sources:
https://pubmed.ncbi.nlm.nih.gov/42249138/
https://www.nature.com/articles/s41591-026-04476-6
https://ir.structuretx.com/news-releases/news-release-details/structure-therapeutics-announces-publication-nature-medicine/
https://www.fiercebiotech.com/biotech/structure-touts-16-weight-loss-aleniglipron-highest-efficacy-oral-glp-1

~~~

Study Finds 150 Minutes Of Weekly Exercise Falls Far Short Of Real Heart Protection
A Macao Polytechnic University analysis of over 17,000 UK Biobank participants found that the standard 150-minute weekly exercise guideline only reduces cardiovascular risk by 8-9%, while achieving a substantial risk reduction of over 30% requires 560-610 minutes a week, three to four times current recommendations. Only 12% of participants hit that higher threshold. Host Dave Asprey breaks down why public health minimums are a floor, not an optimization target, and what listeners serious about cardiovascular protection should actually be aiming for.
Sources:
https://medicalxpress.com/news/2026-05-real-heart-weekly-climbs-current.html
https://www.medicalnewstoday.com/articles/560-610-minutes-weekly-exercise-lower-cardiovascular-risk-heart-health
https://bjsm.bmj.com/content/early/2026/05/19/bjsports-2025-111351

~~~

New Research Clarifies The Mechanism Behind IV Vitamin C's Anti-Cancer Effect
Decades after Linus Pauling's high-dose vitamin C claims were dismissed following failed oral-dose trials, researchers have clarified that Pauling had the mechanism right and the delivery method wrong: IV vitamin C bypasses gut absorption limits to reach plasma concentrations up to 100 times higher than oral dosing, generating hydrogen peroxide that is selectively toxic to cancer cells due to their lower catalase levels. A 2024 University of Iowa study found IV vitamin C combined with chemotherapy doubled overall survival in advanced pancreatic cancer patients. Host Dave Asprey reflects on how this vindicates a decades-old idea that was dismissed for the wrong reasons, and what it means for anyone facing a cancer diagnosis.
Sources:
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01182/full
https://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq
https://medicine.uiowa.edu/news/2024/11/high-dose-iv-vitamin-c-plus-chemotherapy-doubles-survival-advanced-pancreatic-cancer


This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest breakthroughs in neurodegenerative disease, regenerative medicine, metabolic health, and cancer therapeutics, translated into what actually matters for your biology right now. Host Dave Asprey connects clinical trial data, mechanistic research, and decades of context into practical frameworks for taking control of your own health decisions.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: PhenoNet PHENOGENE-1A, inhaled cromolyn Alzheimer's, APOE4 genotype Alzheimer's trial, regenerative astrocytes brain repair, University of Zurich brain regeneration, adult neuroplasticity, keratin bone scaffold, sheep's wool regenerative medicine, collagen vs keratin bone repair, aleniglipron oral GLP-1, Structure Therapeutics weight loss drug, oral semaglutide alternative, exercise minutes cardiovascular risk, 150 minutes exercise guideline, Macao Polytechnic University heart study, IV vitamin C cancer, Linus Pauling vitamin C, ascorbate hydrogen peroxide cancer cells, integrative oncology, biohacking news 2026,

Thank you to our sponsors!
- Visit www.myvitalc.com/davesfav to unlock Dave’s discount
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Alzheimer's Drug Trial
01:43 – Brain Repair Cells
03:07 – Keratin Bone Scaffolds
04:45 – Oral GLP-1 Pill
05:59 – Minimum Effective Exercise
07:26 – IV Vitamin C Revisited
08:12 – Vitamin C Cancer Trial
09:30 – Takeaway
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive Decline

We're excited to bring you another Dave solo education masterclass, this one breaking down the molecule that started the entire nootropics industry: Racetams

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey pulls back the curtain on piracetam and the racetam family, the original nootropics that quietly built the foundation for modern human performance and brain optimization. As the father of biohacking and someone who has taken racetams almost every single day for 25 years, Dave brings firsthand experience most experts simply don't have. He built two Bulletproof-era companies and led the biohacking movement while running this stack daily, and in this episode, he shares exactly how it worked for him.

Dave traces the strange 1964 Belgian lab discovery that forced scientists to invent the word "nootropic" in the first place, then breaks down how these compounds shift acetylcholine, glutamate, and AMPA signaling to improve memory, focus, and neuroplasticity without touching dopamine or spiking your heart rate. He covers the mitochondria and membrane fluidity mechanisms behind the anti-aging and longevity effects, walks through dosing for all five major racetams, and explains who actually benefits versus who's wasting their money.

This is essential listening for anyone serious about biohacking, human performance, functional medicine, and brain optimization. Whether you're stacking supplements for sleep optimization, exploring fasting and ketosis for metabolism, or just trying to think clearer without sacrificing your health, this episode hands you a real framework for hacking cognitive decline before it starts.

You'll Learn:
Why piracetam forced scientists to invent the term "nootropic" and what actually qualifies as one
How racetams change acetylcholine, glutamate, and AMPA signaling without acting like a stimulant
The link between racetams, mitochondria, and neuroplasticity, and why it matters for anti-aging
Dosing breakdowns for piracetam, aniracetam, oxiracetam, pramiracetam, and phenylpiracetam
Who benefits most: aging brains, stroke recovery, athletes, and anyone flying frequently
How to stack racetams with choline, Danger Coffee, and other supplements the smarter not harder way
The regulatory mess keeping safe, tested nootropics out of reach in the US

Thank you to our sponsors!
- ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order.
- Pique | Head over to Piquelife.com/Dave to get 20% off your order.
- OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: piracetam, racetam, nootropics, smart drugs, aniracetam, oxiracetam, pramiracetam, phenylpiracetam, cognitive enhancement, brain optimization, memory improvement, neuroplasticity, mitochondrial function, acetylcholine, glutamate AMPA receptors, choline supplements, CDP-choline citicoline, alpha-GPC, brain fog remedy, stroke recovery cognitive, dementia prevention, biohacking supplements, Dave Asprey nootropics, longevity brain health, focus and concentration, memory recall, cognitive decline aging

Resources:
• Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:10 – Intro
04:30 – Birth of the Nootropic
08:55 – How Racetams Work
12:51 – Membranes & Blood Flow
15:55 – Piracetam: The Original
19:30 – Aniracetam & Others
22:00 – Phenylpiracetam Power
26:37 – Who Benefits & Stacking
32:25 – Safety & Regulation
36:41 – Starter Protocol & Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

UFOs, UAPs, Non-Human Contact & Zero-Point Energy: Dr. Steven Greer on Government Disclosure, Consciousness and the Truth About Extraterrestrial Intelligence

Get ready to have your entire understanding of reality challenged. This episode reveals the science behind non-human intelligence contact, the physics of consciousness, and why the biggest secret in human history could rewrite everything you know about energy, medicine, and human potential.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Steven Greer, a retired emergency physician and founder of the Center for the Study of Extraterrestrial Intelligence. For over 35 years, Dr. Greer has briefed CIA directors, Pentagon officials, and members of Congress on UFO disclosure, built an archive of more than 750 whistleblower testimonies, and pioneered the CE5 Contact protocol used to initiate peaceful contact with non-human craft. His firsthand experiences, government-level access, and decades of documented research make him one of the most credible voices in the disclosure movement.

Dr. Greer and Dave dive into the science of consciousness as a nonlocal field, the zero-point energy technology he believes has been suppressed for 70 years, and how mastering this "hacking" of physics could eliminate scarcity, extend human longevity, and unlock forms of neuroplasticity and human performance most people have never considered. They explore near-death experiences, precognitive dreams, remote viewing, and the idea that a small percentage of people practicing deep meditative states can shift collective consciousness at scale. The conversation also touches on how corruption, fear, and disinformation have kept transformative technology out of public hands, and what it would take for humanity to responsibly manage a disclosure that changes everything.

This is essential listening for anyone into biohacking, human performance, consciousness exploration, longevity, functional medicine, and understanding how the mind and unseen fields of energy shape human potential.

You'll Learn:
Why Dr. Greer believes the U.S. government has had access to anti-gravity and zero-point energy technology since the 1950s
How consciousness functions as a nonlocal field and what that means for human potential and neuroplasticity
The real story behind the Roswell crash and its connection to nuclear weapons testing
How meditation and altered states may unlock remote viewing and precognitive ability
Why Dr. Greer believes only 1% of a population practicing coherent consciousness can shift outcomes for the other 99%
What it would take to responsibly disclose suppressed energy technology without global economic collapse
How fear-based narratives and disinformation campaigns have shaped public perception of non-human contact

Thank you to our sponsors!
- Qualia | Go to qualialife.com/ASPREY for 50% off, and use code ASPREY for an additional 15% off.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.
- Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. Steven Greer, Steven Greer UFO, CE5 Contact protocol, Disclosure Project, UFO disclosure 2026, UAP disclosure government, zero point energy technology, anti-gravity technology suppressed, Roswell crash truth, non-human intelligence contact, extraterrestrial biological entity, remote viewing training, nonlocal consciousness field, Maharishi effect meditation, near-death experience consciousness, Dave Asprey Steven Greer, military industrial complex UFO, Eisenhower alien meeting, whistleblower testimony UFO, consciousness and quantum entanglement

Resources:
• Learn More About Dr. Greer’s Work At: http://drstevengreer.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 — Trailer
01:02 — Intro
02:29 — Evidence & Whistleblowers
08:30 — Free Energy Suppression
12:52 — The Suppressed Tech
20:46 — Who Controls the Cover-Up
28:44 — Roswell & ET History
35:26 — Fake UFOs & Disinformation
39:00 — Threats, Bribes & Going Public
41:46 — Consciousness & CE5
50:13 — Greer's Personal Contact
01:05:20 — Free Energy Entrepreneurship
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This video reveals how your skin uses glutathione to defend itself, how Dr. Nayan Patel solved its delivery problem, and why his topical antioxidant serum was clinically shown to improve the appearance of fine lines, wrinkles, and skin tone in just 1 week.

You’ll also learn:
The molecule (glutathione) behind clinically-backed wrinkle reduction in 7 days
Why oxidative stress, not just low collagen, drives visible skin aging
How free radicals damage collagen, elastin, and skin tone
Why glutathione is the body's "master antioxidant" for skin protection
The 4 barriers any skincare ingredient must survive to actually work (bioavailability)
The delivery system breakthrough (RO-GSH) that finally makes topical glutathione effective
How to use the full glutathione skincare system (serum, copper peptides, vitamin C) for results in one week

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/

Thank you to our sponsors!
PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:
00:00 - Intro
00:19 - Anti-Aging Drug Screening
01:43 - Protein Restriction & Aging
03:36 - New Skin Injectable
05:23 - Arts & Longevity
07:30 - Biohacking Interventions Reviewed
08:51 - Semaglutide & Aging Clocks
09:29 - Closing Takeaways

Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle

Nasal Spray Ingredient Emerges As Unexpected Longevity Candidate In Massive Drug Screen
Researchers mapped 2,358 longevity-associated genes across the body's broader protein and signaling networks, then screened 6,442 approved drugs to see which ones nudged those aging pathways in a healthier direction. Oxymetazoline, the active ingredient in nasal sprays like Afrin, was among 21 standout candidates, with a predicted pathway running through the ACKR3 receptor and connecting to major aging proteins including NF-kB, TP53, and AKT1. Host Dave Asprey explains why this computational screen is a promising research lead rather than a protocol, and why chronic use of a vasoconstricting nasal spray carries real risks regardless of what a network analysis suggests.
Sources:
https://www.inc.com/lucia-auerbach/scientists-screened-6442-drugs-for-longevity-common-nasal-spray-emerged-as-a-surprising-candidate/91381000
https://www.sciencealert.com/medications-already-in-pharmacies-may-slow-aging-and-scientists-are-narrowing-them-down
https://pmc.ncbi.nlm.nih.gov/articles/PMC12425021/

~~
New Review Of 350+ Studies Asks Whether Less Protein Means Longer Life
A review spanning more than 350 studies found that protein restriction consistently extended lifespan and improved metabolic health across mice, rats, flies, and fish, with smaller human studies showing improvements in body fat and fasting glucose even when total calorie intake rose. Researchers point to FGF21, a liver hormone that rises under protein or amino acid scarcity and boosts energy expenditure and glucose regulation, as a key mechanism. Host Dave Asprey breaks down why blanket protein advice fails older adults preserving muscle and highly active people just as badly as it fails everyone else, and why matching intake to actual biology beats maximizing protein at every meal.
Sources:
https://www.medicalnewstoday.com/articles/why-reducing-protein-intake-could-promote-healthy-aging-new-research
https://time.com/article/2026/08/03/eat-less-protein-age-better-live-longer/
https://www.sciencedaily.com/releases/2026/08/260801042811.htm
https://www.cell.com/cell-reports-blue/fulltext/S2949-8821(26)00079-9
https://pmc.ncbi.nlm.nih.gov/articles/PMC8991228/
https://www.eurekalert.org/news-releases/1137190

~~
Processed Cadaver Skin Injectable Enters The Anti-Aging Market As Elravie Re2O
A new injectable called Elravie Re2O, short for "return to your 20s," is made from donated human skin processed to remove living cells and most genetic material, leaving a collagen-rich extracellular matrix that gets injected into the face and neck as a biological scaffold rather than a simple filler. Human-derived tissue matrices already have a track record in burn and wound care, but this specific product is not yet FDA-approved and lacks comparative trial data against existing fillers. Host Dave Asprey separates legitimate regenerative medicine from a novel cosmetic product still waiting on long-term safety and consistency data.
Sources:
https://nypost.com/2026/07/21/health/the-hottest-new-anti-aging-treatment-cadaver-skin/
https://www.newsobserver.com/living/article316698211.html
https://www.miamiherald.com/living/article316698295.html
https://pmc.ncbi.nlm.nih.gov/articles/PMC12985180/
https://laboderm-skin.com/elravie-re2o-application/

~~
UCL Study Finds Weekly Arts Engagement Tracks With Slower Epigenetic Aging
A University College London study of more than 3,500 adults found that people who engaged weekly with arts and culture, including painting, music, museums, and theater, showed a roughly four percent slower pace of aging on the DunedinPACE clock and appeared about one biological year younger on PhenoAge, with the effect holding after adjusting for income, education, smoking, and physical activity. Benefits appeared whether people were actively creating art or simply attending performances and exhibits. Host Dave Asprey argues this expands what counts as a health input beyond molecules and devices, since novelty, meaning, and social connection influence the nervous system too.
Sources:
https://www.npr.org/2026/05/12/nx-s1-5818172/study-arts-slow-biological-aging
https://www.news-medical.net/news/20260511/Regular-arts-engagement-may-help-slow-biological-aging-process.aspx
https://studyfinds.com/arts-culture-may-slow-aging/

~~
Review Of 41 Human Studies Ranks Which Interventions Actually Shift Epigenetic Clocks
A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, semaglutide, pitavastatin, and ketamine, while nicotinamide riboside, rapamycin, and senolytics showed no detected clock improvement in the studies reviewed. Semaglutide produced the strongest single result, slowing DunedinPACE by about nine percent in a trial of adults with HIV-associated fat redistribution, though a separate fatty liver study produced mixed outcomes. Host Dave Asprey explains why a strong mechanistic story does not guarantee a moved biomarker, and why clinical outcomes, functional measures, and safety data all matter alongside any single clock reading.
Sources:
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1836446/full
https://pubmed.ncbi.nlm.nih.gov/42294499/
https://www.news-medical.net/news/20260616/Semaglutide-omega-3s-and-diet-shift-epigenetic-aging-clocks-in-human-studies.aspx
https://www.nature.com/articles/s41514-026-00383-9
https://pmc.ncbi.nlm.nih.gov/articles/PMC12338914/
https://medicalxpress.com/news/2026-06-popular-glp-drug-biological-aging.html
https://www.creativebiomart.net/blog/semaglutide-may-slow-epigenetic-aging-in-humans
https://www.aging-us.com/article/202913/text
https://superpower.com/guides/can-you-reverse-epigenetic-age
https://www.nature.com/articles/d41586-026-01836-7
https://www.businessinsider.com/first-ever-reverse-aging-drug-was-just-injected-into-a-human-2026-6
~~

This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into a computational drug-repurposing screen, the case for eating less protein, a new regenerative injectable made from human tissue, the biological effect of creative engagement, and a data-driven ranking of which longevity interventions actually move epigenetic clocks. Host Dave Asprey connects computational biology, nutrition science, regenerative medicine, and biomarker research into practical frameworks for evaluating what belongs in a real longevity protocol versus what belongs on a watch list.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: oxymetazoline longevity, drug repurposing screen aging, ACKR3 receptor aging pathway, protein restriction longevity, FGF21 hormone aging, low protein diet healthspan, cadaver skin injectable, Elravie Re2O, extracellular matrix regenerative medicine, anti-aging injectable 2026, arts engagement biological age, DunedinPACE epigenetic clock, PhenoAge biological age, epigenetic clock interventions, semaglutide epigenetic aging, rapamycin epigenetic clock, senolytics human trials, biological age testing, biohacking news 2026, Dave Asprey, The Human Upgrade

Thank you to our sponsors!
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Intro
00:19 – Anti-Aging Drug Screening
01:43 – Protein Restriction & Aging
03:36 – New Skin Injectable
05:23 – Arts & Longevity
07:30 – Biohacking Interventions Reviewed
08:51 – Semaglutide & Aging Clocks
09:29 – Closing Thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.