Saltar al contenido
PodcastsCienciasThe Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
Último episodio

1566 episodios

  • The Human Upgrade: Biohacking for Longevity & Performance

    The $18 Million Pills Nobody Can Explain | Igniton : 1510

    30/07/2026 | 55 min
    Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and Longevity

    There's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes inside the lasers, vacuum chambers, and cold plasma behind the new science of quantum-charged supplements.

    Get 15% off your next purchase at: igniton.com/dave

    Host Dave Asprey sits down with Ashley Grace, an executive working directly with Igniton, the company behind a new category of supplements charged with particles pulled from the surface of the sun.

    Dave and Ashley dig into the science and the story behind Igniton: an $18 million private lab built to recreate solar conditions here on Earth, peer-reviewed studies showing major gains in memory, attention, and sleep, and the strange psychological and even bordering-on-supernatural shifts users report after months on the product. They also get into coherence, cellular entropy, and why some of the biggest breakthroughs in human performance and longevity may come from fields and frequencies rather than another pill.

    This episode is essential listening for anyone into biohacking, nootropics, sleep optimization, brain optimization, and the cutting edge of anti-aging and functional medicine.

    You'll Learn:
    How Igniton's lab uses vacuum chambers, cold plasma, and lasers to charge supplement ingredients at a subatomic level
    The clinical results behind the cognition formula, including gains in mental performance, attention, and short-term memory
    Why the sleep formula showed a 25 percent increase in REM sleep in just two weeks, verified with wearables like Oura and Apple Watch
    How charged hydrogen may be boosting bioavailability of nootropics tied to neuroplasticity and mitochondria function
    The unexpected personal experiences, from heightened intuition to emotional regulation, that both Dave and Ashley report after sustained use
    Why longevity markers like IL-6 and CRP dropped in Igniton's clinical trials, and what that means for anti-aging and metabolism
    The next frontier for the company: a chair-based coherence technology already tested by NASA


    Thank you to our sponsors!
    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    - Neuronic | Go to www.neuronic.online Code DAVE for $100 off
    - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
    - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Igniton supplement review, subatomic particle supplement, quantum charged supplements, does Igniton work, Igniton sleep formula REM, Igniton cognition supplement, Jirka Rysavy Gaia, holoton NASA chair, cold plasma supplement technology, charged hydrogen bioavailability, Igniton clinical study results, Igniton vs placebo study, best nootropic for focus 2026, supplements for REM sleep, quantum technology longevity, Igniton.com discount code, Ashley Grace Charlotte's Web, coherence and cellular aging, energy healing biohacking, intuition and meditation supplements

    Resources:
    • Get 15% off your next purchase at: igniton.com/dave
    • Visit https://igniton.com to learn more about their processes and offerings
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:32 – Show Intro
    06:15 – What Are Ignitons?
    13:29 – How Ignitons Are Made
    17:31 – Coherence & Longevity
    22:18 – Water Molecule Charging
    26:25 – Sleep Formula & REM Results
    32:02 – Yogic Siddhis & Superpowers
    38:43 – Dave's Amplified Abilities
    43:31 – Energy Healing
    46:22 – Consciousness Scale & Muscle Testing
    51:08 – Discount Code Offer
    55:12 – Closing
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    I Grew My Penis 2 Inches (What Works, And What Doesn't) | Alex Tatem : 1509

    28/07/2026 | 58 min
    Urologist Dr. Alex Tatum on Girth Enhancement, Testosterone, and Peptide Therapy

    Most men will never ask their doctor the questions this episode answers. From safe, non-surgical girth enhancement to daily testosterone dosing to the peptides fighting for FDA access right now, this conversation covers what actually works, what's dangerous, and what your doctor probably won't bring up first.

    Host Dave Asprey sits down with Dr. Alex Tatem, a board-certified urologist with fellowship training in male sexual and reproductive medicine. Dr. Tatem has built his practice and his YouTube following around pushing medicine beyond what the traditional medical establishment allows, with a focus on male girth enhancement, performance enhancement, peptides, and PEDs.

    They break down the real science behind penis enhancement, including why length surgery still does not exist, how hyaluronic acid injections safely increase girth, and why silicone and PMMA fillers have left men permanently disfigured. Dave and Dr. Tatem also get into cutting-edge testosterone dosing strategies, the peptides driving the biggest gains in human performance and longevity, including BPC-157, TB-500, SS-31, and MOTS-c, and why PT-141 has become the most talked-about peptide for libido and sexual health.

    You'll Learn:
    Why hyaluronic acid injections have become the safest, most reproducible method for girth enhancement
    The truth about penis enlargement surgery, and why length enhancement still has no reliable surgical fix
    How daily microdosed testosterone compares to traditional weekly TRT protocols
    Why PT-141 and melanotan II are being used for libido, nitric oxide release, and even prostate health
    How BPC-157, TB-500, SS-31, and MOTS-c are changing recovery, mitochondria function, and metabolism
    The dangerous enhancement trends to avoid, including silicone implants and unregulated fillers
    Why the fight over peptide access at the FDA could determine the future of functional medicine and supplements in America

    Thank you to our sponsors!
    - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey
    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
    - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
    - ALP | Head to http://alppouch.com/ and use code DAVE for 20% off your first order.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: penis girth enhancement hyaluronic acid, penis enlargement that actually works, average penis size urologist, PT-141 for libido, melanotan II peptide, BPC-157 benefits, TB-500 for injury recovery, SS-31 dosing, MOTS-c peptide FDA, daily subQ testosterone dosing, oral testosterone undecanoate, TRT dosing protocols, Anavar for muscle recovery, silicone penile implant risks, PMMA filler complications, is penis enlargement surgery safe, hyaluronic acid girth injection cost, Dr. Alex Tatem urologist, peptides FDA regulation 2026

    Resources:
    • Check Out Dr. Tatem’s Content At: https://www.youtube.com/@DrAlexTatem
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    03:10 – Penis Enhancement Intro
    13:32 – Dangerous Enhancement Methods
    22:49 – Girth Procedure Explained
    29:56 – Why Demand Is Rising
    32:09 – Peptides for Men
    41:26 – TRT and Testosterone
    50:35 – Peptide Regulation Fight
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Does This Sleep Fasting Hack Actually Cut Cortisol? : 1508

    26/07/2026 | 10 min
    You’ve probably tried everything to sleep better. Magnesium. Melatonin. Blackout curtains. Maybe even expensive sleep gadgets. But what if the real reason your sleep feels broken has nothing to do with any of those things?

    In this video, Dave Asprey explains a hidden biological process that controls whether your body stays in stress mode at night… or finally switches into deep recovery mode. He breaks down why so many people wake up exhausted, why cortisol stays elevated while you sleep, and why your body may never fully enter repair mode even if you’re technically asleep.

    You’ll learn how one overlooked habit affects your brain, metabolism, recovery, heart rate, and overnight repair systems, plus the surprising research that showed dramatic changes in sleep quality from a single adjustment. Once you understand this mechanism, you’ll never look at sleep the same way again.

    Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
    Try TrueDark glasses: https://truedark.com
    Try Danger Coffee: https://dangercoffee.com/discount/davetube
    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

    The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

    Thank you to our sponsors!
    PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
    Viome | Check it out at viome.com and use code 16DAVE for 16% off. It’s time to stop guessing and start knowing your body.
    iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    00:00 – Trailer
    00:53 – Sleep Environment Matters
    03:44 – Red Light Bulbs
    04:50 – Blackout Curtains
    05:16 – Light-Blocking Glasses
    07:16 – Morning Supplement Stack
    07:41 – Creatine for the Brain
    11:48 – MCT Oil Fuel
    13:06 – Cellular Cleanup (Autophagy)
    15:12 – Magnesium for Sleep
    16:56 – Full Stack Recap
    18:26 – Biohacking Is Accessibl

    Connect with Dave Asprey!

    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast: https://www.instagram.com/
    TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/
    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
    Upgrade Labs: https://upgradelabs.com
    40 Years of Zen: https://40yearsofzen.com
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Diet Soda Brain Aging, Hidden Heart Attack Risk, New Cholesterol Pill, Lettuce Recall, and more... : 1507

    24/07/2026 | 12 min
    Artificial Sweeteners & Cognitive Decline, Myosteatosis on Coronary CT, Merck's Oral PCSK9 Inhibitor, Cyclospora Outbreak, Gut-Brain Synchronization, and the Banana Smoothie Mistake Explained

    Artificial Sweeteners Linked To 62% Faster Cognitive Decline In Landmark Brazilian Study
    A study tracking more than 12,700 adults (average age 52) over eight years found that people consuming the most artificial and low-calorie sweeteners, roughly 191 mg a day, about what's in a single can of diet soda, showed cognitive decline 62% faster than the lowest-intake group, equivalent to 1.6 extra years of brain aging, with memory hit hardest. Six of the seven sweeteners tested, including aspartame, saccharin, and acesulfame K, were linked to faster decline; tagatose was the lone exception. Researchers point to gut-microbiome disruption, altered glucose and insulin signaling, and possible direct neuronal effects as plausible mechanisms. Host Dave Asprey breaks down why a dose this small was enough to move the curve, why tagatose deserves more scrutiny before being called "safe," and where diet products' short-term weight-loss marketing conveniently ignores the long-term cost to your brain.
    Source:
    https://www.inc.com/kevin-haynes/study-links-cognitive-decline-to-surprisingly-small-daily-amount-of-artificial-sweeteners/91376522
    ~~
    AI Analysis Of 1,722 Heart Scans Finds Muscle Quality Predicts Heart Attacks Independent Of Calcium Score
    Using data from the SCOT-HEART trial, a University of Edinburgh team ran an AI model against ten years of coronary CT angiogram scans, measuring skeletal muscle attenuation, a marker of myosteatosis, or fat infiltration into muscle tissue. Every 10-point increase in muscle density corresponded to a 31% lower heart attack risk and 39% lower all-cause mortality over the following decade, and critically, this held independent of coronary calcium score, the current gold-standard risk marker. The same low-density-muscle patients also showed higher lung attenuation, lower liver attenuation, and more torso fat volume, a pattern consistent with systemic insulin resistance rather than a muscle-specific issue. Host Dave Asprey unpacks why calcium score isn't capturing the full risk picture, why myosteatosis is really a readout of whole-body insulin sensitivity, and what he'd add to a routine workup on top of a calcium score.
    Source:
    https://www.theguardian.com/science/2026/jun/30/strong-chest-back-less-likely-heart-attack-analysis
    ~~
    FDA Approves First Oral PCSK9 Inhibitor, Cutting LDL By Up To 60% Without Injections
    Merck's enlicitide (brand name Lipfendra) is now FDA-approved as the first once-daily oral PCSK9 inhibitor, lowering LDL cholesterol by up to 60% in a phase 3 trial of 2,912 patients, routinely bringing levels down to 50-60 mg/dL. It works by blocking PCSK9, a liver protein that tags LDL receptors for destruction, the same target as injectable drugs like Repatha and Praluent, which have shown roughly 20% reductions in heart attacks and strokes in high-risk patients. Lipfendra is priced at $315 for a 30-day supply, with no excess side effects reported versus placebo over six months, though long-term outcome data is still pending. Host Dave Asprey explains why crushing total LDL without checking ApoB, LDL particle number, or oxidized LDL is optimizing the wrong variable, and what he'd want on his labs before considering a drug like this.
    Sources:
    https://www.nytimes.com/2026/07/16/science/the-fda-approves-a-new-pill-to-slash-cholesterol-levels.html
    https://www.cnbc.com/2026/07/16/mercks-cholesterol-pill-gets-us-fda-approval.html
    ~~
    Cyclospora Outbreak Tied To Taylor Farms Lettuce Spreads To 34 States, Prompts Nationwide Recall
    Federal investigators have linked a multistate cyclosporiasis outbreak to shredded iceberg lettuce from Taylor Farms de Mexico, with Michigan alone logging over 5,000 cases and 100+ hospitalizations, much of it traced to lettuce used at Taco Bell. Taylor Farms has recalled all iceberg lettuce sourced from central Mexico, and Walmart has pulled Marketside Iceberg Salad and Marketside Shredded Lettuce with specific date codes across 27 states. Cyclospora spreads through fecal contamination and causes weeks of watery, explosive diarrhea if untreated; washing doesn't reliably eliminate it, since the parasite requires heat above 158°F to inactivate. Host Dave Asprey explains why pre-washed, pre-cut bagged greens remain a recurring contamination risk no matter what the label claims, and connects the outbreak's gut damage to lingering gut-brain consequences long after symptoms resolve.
    Sources:
    https://www.usatoday.com/story/news/health/2026/07/18/taylor-farms-shredded-lettuce-sample-cyclospora/90969103007/
    https://www.fda.gov/food/outbreaks-foodborne-illness/investigation-5-state-outbreak-cyclospora-illnesses-iceberg-lettuce-july-2026
    ~~
    New Research Links Excessive Gut-Brain Synchronization To Anxiety And Depression
    Emerging research on the enteric nervous system, which contains over 100 million neurons and sends more signals to the brain than it receives, finds that when the gut's electrical rhythm synchronizes too tightly with the brain's, that over-coupling correlates with higher rates of anxiety and depression. The gut communicates with the brain through the vagus nerve, hormones, and immune signaling, and dysbiosis or ENS dysfunction has separately been linked to mood disorders in both human and animal studies. Host Dave Asprey breaks down why the goal isn't maximum gut-brain connection but the right kind of connection, questions whether the coupling is driving the anxiety or the anxiety is driving the coupling, and makes the case for treating mood from the gut up instead of the brain down.
    Source:
    https://refractor.io/medical/enteric-nervous-system-brain-link-mental-health/
    ~~

    Rhonda Patrick Explains Why She Never Adds Bananas To Her Berry Smoothies

    Rhonda Patrick has been telling audiences she skips bananas in her berry smoothies because of polyphenol oxidase, an enzyme in bananas that degrades the polyphenols in blueberries linked to improved cognition and vascular health, based on in-vitro and food chemistry data. She now builds her smoothies on an avocado base instead, and notes that vitamin C from citrus can partially inhibit the enzyme for anyone unwilling to drop the banana. Host Dave Asprey weighs in on the gap between lab chemistry and clinical outcome data, why that gap doesn't make the mechanism any less real, and why this is a low-cost swap worth making even without a human trial behind it.

    Sources:
    https://www.reddit.com/r/Biohackers/comments/1v2jbib/dr_rhonda_patrick_i_dont_add_bananas_to_my/
    https://www.foundmyfitness.com/episodes/polyphenol-oxidase-bananas-smoothies
    ~~

    This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insight into a sweetener risk hiding in everyday diet products, a heart attack predictor buried inside routine CT scans, the tradeoffs of a new cholesterol drug, a produce recall worth paying attention to, the science behind gut-driven anxiety, and a smoothie mistake that's quietly undercutting your polyphenol intake. Host Dave Asprey connects clinical research, cohort data, and food chemistry into practical frameworks for protecting brain health, cardiovascular health, and gut-brain resilience.

    New episodes every Tuesday, Thursday, Friday, and Sunday.

    Keywords: artificial sweeteners cognitive decline, aspartame brain aging, tagatose safety, diet soda memory loss, myosteatosis coronary CT, skeletal muscle attenuation heart attack, SCOT-HEART trial, coronary calcium score insulin resistance, enlicitide Lipfendra FDA approval, oral PCSK9 inhibitor, LDL particle number ApoB, cyclospora outbreak 2026, Taylor Farms lettuce recall, cyclosporiasis symptoms treatment, enteric nervous system anxiety, gut brain synchronization, vagus nerve mental health, Rhonda Patrick polyphenol oxidase, banana blueberry smoothie mistake, biohacking news 2026, Dave Asprey, The Human Upgrade

    Thank you to our sponsors!
    - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com.
    - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Intro
    00:19 – Story 1: Artificial Sweeteners
    02:05 – Story 2: Muscle Fat & Heart Risk
    04:36 – Story 3: PCSK9 Cholesterol Pill
    06:27 – Story 4: Cyclospora Lettuce Outbreak
    07:56 – Story 5; Gut-Brain Axis & Anxiety
    09:29 – Story 6: Banana vs. Blueberry
    11:08 – Predictions for Next 5 Years
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506

    23/07/2026 | 1 h 7 min
    Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan

    Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do.

    Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription.

    Host Dave Asprey sits down with research microbiologist Kiran Krishnan, co-founder of Microbiome Labs, the leading microbiome therapeutics brand among healthcare professionals. He has published multiple peer-reviewed studies, holds global patents, and has spent 20 years building companies focused on the science of the microbiome. His work centers on spore-based probiotics, the rare strains proven to survive the stomach's brutal acidity and actually rebuild the gut from the inside out.

    Kiran and Dave break down why 98 percent of conventional probiotics die before they ever reach your gut, and why spore-forming bacteria are different. They dig into the "gelding effect," the well-documented pathway where endotoxins from bad gut bacteria shut down testosterone production and drive up cortisol, and how fixing your microbiome can reverse it. They cover the connection between endotoxemia and nearly every major marker of aging, metabolism, and inflammation, why butyrate acts like a natural GLP-1 for fat loss, how Akkermansia can upregulate mitochondria and improve blood sugar control, and the surprising role vitamin K2 plays in bone density and functional medicine. This is biohacking at the cellular level, using ancient biology, fasting-adjacent metabolic pathways, and precision supplementation to optimize human performance from the gut up.

    You'll Learn:
    Why 98 percent of probiotics die in your stomach before they ever work
    What the "gelding effect" is and how gut bacteria can shut down testosterone
    How endotoxins drive inflammation, cortisol, and accelerated aging
    Why butyrate functions like a natural, low-cost alternative to GLP-1 drugs
    How Akkermansia improves mitochondrial function and blood sugar control
    The overlooked link between your microbiome and vitamin K2 production
    Why spore-based probiotics can survive gastric acid when most others cannot
    How 90 days of gut repair can measurably reduce circulating endotoxins

    Keywords: best probiotics that survive stomach acid, spore based probiotics benefits, gelding effect testosterone, endotoxins and testosterone, how to lower endotoxins, LPS gut bacteria, Akkermansia GLP-1 natural, gut bacteria and belly fat, vitamin K2 bone density, Kiran Krishnan microbiologist, Just Thrive probiotic, leaky gut symptoms, microbiome and testosterone, fecal transplant benefits, Dave Asprey, biohacking, longevity

    Resources:
    • Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription
    • Learn More About All Of Just Thrive’s Offerings At: https://justthrivehealth.com/
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Thank you to our sponsors!
    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.
    - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order.
    - Show notes - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com

    Timestamps:
    00:00 – Trailer
    00:38 – Kiran Intro
    02:01 – Stomach Acid & Probiotics
    05:25 – Fauci & Spore Bacteria
    13:58 – Losing Gut Diversity
    19:01 – How Butyrate Is Made
    22:11 – Dave's Personal Stack
    24:00 – Quorum Sensing
    31:26 – Endotoxins Explained
    37:13 – Charcoal & Binders
    39:41 – SIBO & Gut Bacteria
    45:03 – Discovering Vitamin K2
    49:33 – Gelding Effect & Testosterone
    54:51 – Akkermansia & Weight Loss
    01:02:17 – Role of Bitters
    01:04:47 – Just Thrive Gift
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Más podcasts de Ciencias
Acerca de The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Sitio web del podcast

Escucha The Human Upgrade: Biohacking for Longevity & Performance, StarTalk Radio y muchos más podcasts de todo el mundo con la aplicación de radio.es

Descarga la app gratuita: radio.es

  • Añadir radios y podcasts a favoritos
  • Transmisión por Wi-Fi y Bluetooth
  • Carplay & Android Auto compatible
  • Muchas otras funciones de la app