Grow Everything Biotech Podcast

Nick Milne, founder of Octarine Bio, joins Grow Everything to unpack how biology can reshape the future of color. In this episode, Nick explains why synthetic dyes have dominated textiles for more than a century, why sustainability alone is not enough to drive adoption, and how Octarine is building bio based pigments that can compete on performance, price, and scale. The conversation explores the environmental and human health problems tied to petrochemical dyes, especially azo dyes used in polyester, while showing how precision fermentation can create high strength pigments that work as drop in replacements for existing dye house workflows. Nick also shares how Octarine thinks about scale up, regulatory pressure in Europe, investor expectations, product development, and the practical realities of bringing biotech products into old and highly cost sensitive industries.
Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and speak with the leaders and innovators using biology to change the world. Biology is the world’s oldest technology, and it can be engineered. So, what are we growing?
Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
Chapters:
(00:00:00) Nick previews Octarine’s high strength pigment platform
(00:00:23) Karl and Erum open with science policy, AI, biosecurity, and discovery in nature
(00:12:18) Introducing Nick Milne and Octarine Bio’s mission to rewrite color with biology
(00:14:03) Why biology can outperform chemistry in rare but powerful commercial use cases
(00:16:21) The slow shift from petrochemical dyes to bio based alternatives in textiles
(00:18:31) What Pure Palette looks like as a drop in replacement for synthetic dyes
(00:20:13) Octarine’s color pipeline, from purple and black to green, blue, red, and yellow
(00:21:39) How stronger pigments create a path toward price parity for textile customers
(00:28:13) Why European regulation may accelerate sustainable color adoption
(00:31:15) Scale up, consistency, azo dyes, and lessons for biotech founders
Links and Resources:
Octarine Bio
Octarine Bio - PurePalette
Nick Milne LinkedIn
Octarine Bio secures €5M to scale bio-based pigments
Ginkgo Bioworks and Octarine Bio Partnership Achieves Initial Success in Advancing Sustainable Dye Production
Science, A New Golden Age
Kristin Ellis’ Substack commentary on Science, A New Golden Age
Neuromancer Apple TV trailer
A new species of Colobus monkey from the Lomami National Park, Democratic Republic of Congo
BioInnovations Events - For 25% off use code: Grow Everything
Grow Everything LinkedIn
Topics Covered:
Octarine Bio, bio-based pigments, synthetic dye replacement, sustainable textile dyes, fermentation-derived colors, metabolic engineering, azo dye alternatives, textile color sustainability, precision fermentation pigments, sustainable fashion materials
Have a question or comment? Message us here:
Text or Call (804) 505-5553
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Music by: Nihilore 
Production by: Amplafy Media

Have you ever wondered why the color in your clothes can be so harmful to the environment? In this episode of the Grow Everything Podcast, Karl and Erum continue their BioDye series with Roya Aghighi, founder of Lite-1. Roya grew up in her mother’s fashion studio and later worked in the industry testing new materials, but she decided to leave after seeing the pollution caused by traditional dyeing methods. She explains how Lite-1 uses engineered microbes to produce colorful pigments through fermentation, beginning with black, one of the most difficult and damaging colors to make sustainably. Roya also discusses why natural variation in biology can be useful rather than a problem, and why the biggest challenge facing biological dyes may be getting brands and investors to share the risks of developing them. She predicts that color could eventually become an important tool for tracking a garment throughout its life. Before the interview, Karl and Erum also discuss radiation-loving microbes, cuts to pathogen testing, and organisms designed with the help of computers.
Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and speak with the leaders and innovators using biology to change the world. Biology is the world’s oldest technology, and it can be engineered. So, what are we growing?
Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
Chapters:
(00:00:00) Biology as a technology and why textile dye is so harmful
(00:05:00) Microbe expeditions, Bikini Atoll, and a Cyclospora outbreak
(00:10:30) Cuts to pathogen monitoring and organisms designed with computers
(00:16:40) Meet Roya Aghighi, from growing up in a fashion studio to founding a biotech company
(00:22:45) How Lite-1 uses fermentation to create a more sustainable black dye
(00:28:30) Why biological variation can be useful information
(00:34:30) Focusing on performance, testing, and regeneration instead of sustainability alone
(00:40:30) The challenges of cost, scale, and shared risk in the biological dye market
(00:47:00) Product standards, traceability, and the next premium opportunity in fashion
(00:52:00) Quick-fire questions and final thoughts from the hosts
Links and Resources:
Lite-1 Bio 
Roya Aghighi
177. Dye Another Day (REPLAY): The New Way to Color Textiles with Colorifix's Orr Yarkoni
178. Pretty in Pigments: Jesse Adler Colors the Future with Pitri
180. Fungi in Full Color: Ricky Cassini Reimagines Dye at Michroma
181. Can Hue Believe It? Gerit Tolborg’s Quest for Pure Color at Chromologics
The Next 500 years - Chris Mason
BioAstra
Grow Everything LinkedIn
BioInnovations Events - For 25% off use code: Grow Everything
Topics Covered:
biological dyes, microbial color production, sustainable black dye, textile dye pollution, fermentation-based colorants, bio-based textile dyes, regenerative fashion, traceable garment dyes, synthetic dye alternatives, Lite-1 Bio
Have a question or comment? Message us here:
Text or Call (804) 505-5553
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Music by: Nihilore 
Production by: Amplafy Media

With Episode 200 coming up, Karl and Erum switch roles and interview each other the way they usually interview their guests. Karl shares why he decided not to become a doctor, how interviewing bands in college taught him to connect with anyone, and what he learned about storytelling during a decade in public relations before starting Messaging Lab. Erum talks about her unexpected path from studying forensic chemistry and working in pharmaceutical labs to executive coaching, joining a startup accelerator on a ship traveling around the world, and working in energy policy from the Navajo Nation to Brussels. They also discuss what waiting tables taught them about sales and humility, why early-stage startups should sometimes stay quiet until they have real traction, and why strong relationships are something AI cannot replace. Along the way, they revisit favorite moments from past guests, including Vishaal Bhuyan, Casey Lardner, Glennis Mehra, Linnea Fletcher, Elizabeth Hénaff, Phil Morle, Michael Specter, and Sabriya Stukes. Their conversation is a reminder that there is no single path into the bioeconomy.
Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and speak with the leaders and innovators using biology to change the world. Biology is the world’s oldest technology, and it can be engineered. So, what are we growing?
Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
Chapters:
(00:00:00) Karl and Erum interview each other ahead of Episode 200
(00:06:45) Erum’s experience building a startup at sea with the Unreasonable Institute
(00:13:30) Genspace’s Break Into Biotech program and lessons from college
(00:19:58) Leaving the pharmaceutical lab for positive psychology and executive coaching
(00:26:40) What working in restaurants teaches about sales, empathy, and humility
(00:33:20) How energy and water policy work with the Navajo Nation shaped Erum’s perspective
(00:40:02) Why staying quiet can be better than making a big launch announcement for an early-stage biotech company
(00:46:31) Michael Specter discusses mistrust in science and the need for greater biology education
(00:53:15) Career changes, layoffs, and staying adaptable in the age of AI
(00:59:58) Advice for their younger selves and quick-fire questions
Links and Resources:
45. Insuring Your Lunch: Aanika’s Vishaal Bhuyan Cracks the Microbial Code of Food Security
139. Cultivating a Culture of Cultures? Genspace's Casey Lardner on Community Biotech
30. Breaking into Biotech: Linnea Fletcher's Inclusive Education and Workforce Upskilling at InnovATEBIO
117. From Lab Coats to CEO Notes: BioLabs' Glennis Mehra on Biotech Business in NYC
104. Unseen Worlds: Exploring Environmental Microbiomes and Their Secrets of Human and Climate Impact with Dr. Elizabeth Henaff
149. Beyond Capital: Phil Morle of Main Sequence Ventures on Collaboration as the New Competitive Edge
44. Spec-Tacular Science: A Chat with Michael Specter on Denying Denialism
39. From Microbe to Unicorn: IndieBio's Sabriya Stukes on the Journey of Biotech Startups
AI Value Pyramid
Grow Everything LinkedIn
BioInnovations Events - For 25% off use code: Grow Everything
Topics Covered:
community biotech, biotech storytelling, biotech founders, biotech communications, life lessons in biotech, biotech careers, science entrepreneurship, biotech media, biotech community building, biotech journey

Have a question or comment? Message us here:

Text or Call (804) 505-5553
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Music by: Nihilore 

Production by: Amplafy Media

Lisa Ressler has spent more than 35 years working in science-based businesses, including DuPont and Evonik, and now serves as Chief Commercial Officer at Amyris. In this conversation, she joins Karl and Erum to discuss where Amyris stands today, what the company learned from Chapter 11, and why returning its focus to B2B science was the right move. Lisa explains the company’s 1.5 million-liter fermentation facility in Barra Bonita, Brazil, its partnership with Wacker to develop bio-based personal care ingredients, and the simple framework she uses to decide which markets are worth pursuing. She also shares what it takes for a bio-based ingredient to move beyond higher “green” pricing and reach large-scale commercial use, making the case that strong performance is ultimately what convinces customers.
Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and influencers changing the world by growing everything. Biology is the oldest technology. And it can be engineered. What are we growing?
Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
Chapters:
(00:00:00) - Introduction and catching up after the Fourth of July
(00:05:00) - Soil health, regenerative agriculture, and current biotech trends
(00:10:00) - Biomanufacturing in China and the global race for scale and speed
(00:15:00) - Meet Lisa Ressler, Chief Commercial Officer at Amyris
(00:19:00) - What Amyris produces and how it works with partners across the supply chain
(00:24:00) - Amyris’s return to B2B and what enterprise customers want after Chapter 11
(00:31:00) - How Amyris and Wacker collaborate from research through development
(00:37:00) - Proprietary molecules and how Amyris chooses which markets to pursue
(00:41:00) - Exploring Amyris’s molecule portfolio, from squalane to vaccines
(00:48:00) - The future of precision fermentation and quick-fire questions
Links and Resources:
Amyris
Lisa Roessler
Amyris' sustainable squalene
Amyris, Inc. Launches New Production Line at Brazil Precision Fermentation Plant
WACKER and biomanufacturing pioneer Amyris join forces in the personal-care sector
179. D.C. Climate Week LIVE: The Road to Remake Everything
183. The American Biotech Blueprint: Senator Todd Young on Biodiversity as National Security
73. At the Bleeding Edge: Cresilon's Joe Landolina on Rapid Wound Care
141. Gut Check! Viome’s Momo & Guru Decode Your Inner Microbiome
158. Mycelium On, Sound Off: How GOB's Lauryn Menard Makes Biomaterials Feel Like Culture
SilvaBio and Foray Bioscience Announce Acceleration to Restore the American Chestnut
Common Ground - agriculture documentary
Siphonophore - longest animal
BioInnovations Events - For 25% off use code: Grow Everything
Topics Covered:
precision fermentation, Amyris, squalane, sustainable beauty ingredients, bio-based chemistry, PFAS alternatives, industrial biotechnology, synthetic biology, vaccine adjuvant squalene, green chemistry
Have a question or comment? Message us here:
Text or Call (804) 505-5553
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Music by: Nihilore 
Production by: Amplafy Media

Vanessa Vongsouthi, Research Founder and Head of Bioengineering at Samsara Eco, joins host Erum on the Grow Everything Podcast to discuss how engineered enzymes and AI are making it possible to recycle textiles and plastics repeatedly. Vanessa explains how Samsara uses AI-assisted protein design and ancestral sequence reconstruction to create enzymes that break down complex polymers, including Nylon 6,6, into their original chemical building blocks. Those materials can then be returned to existing supply chains and used to create virgin-equivalent products that are indistinguishable from materials made from petrochemicals. She also shares the story behind the world’s first enzymatically recycled Nylon 6,6 jacket, created in partnership with Lululemon, and explores how Samsara Eco was built through Main Sequence Ventures’ orchestration model alongside partners such as Woolworths and the Australian National University. The conversation also looks at what a future built around distributed, local recycling infrastructure could mean for designers, manufacturers, consumers, and the global circular economy.
Grow Everything brings the bioeconomy to life. Hosts Karl Schmieder and Erum Azeez Khan share stories and interview the leaders and innovators changing the world through biology. Biology is the world’s oldest technology, and it can be engineered. So, what are we growing?
Learn more at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.messaginglab.com/groweverything⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
Chapters:
(00:00:00) - Intro: Heat waves, climate impacts, and the bioeconomy
(00:03:00) - Would Big Tech buy a pharmaceutical company?
(00:08:00) - Brewed human collagen: Gelatech x Hugel partnership
(00:10:00) - France bans fast fashion: Shein, Temu, and the Atacama Desert
(00:13:00) - Introducing Vanessa Vongsouthi of Samsara Eco
(00:17:00) - Biology as future industrial infrastructure
(00:22:00) - Programming enzymes with AI and ancestral sequence reconstruction
(00:29:00) - The Lululemon jacket: proof that enzymatic recycling scales
(00:35:00) - Distributed recycling and a circular material economy
(00:42:00) - Post-interview debrief and key takeaways
Links and Resources:
Forbes - Vanessa Vongsouthi
Samsara Eco
Samsara Eco - LinkedIn
How Samsara Eco made a jacket with Lululemon from enzymatically recycled polyester
lululemon and Samsara Eco Announce 10-Year Plan to Advance Recycled Material Portfolio
The world has an anchovy problem
AI Age Anthropic launches AI drug discovery program, joining tech giants in betting on healthcare
FDA to fast-track food as medicine
Jellatech Partners with South Korea’s Hugel to Bring Cell-Cultured Human Collagen to Market
French parliament passes fast fashion bill targeting Shein and Temu
149. Beyond Capital: Phil Morle of Main Sequence Ventures on Collaboration as the New Competitive Edge
45. Insuring Your Lunch: Aanika’s Vishaal Bhuyan Cracks the Microbial Code of Food Security
122. Ecohacking the Planet: Daniel Goodwin of Homeworld Collective Brews Up Planetary-Scale Solutions
175. Seaweed Is the New Oil: Mari Granström Builds Origin by Ocean
Grow Everything LinkedIn
BioInnovations Events - For 25% off use code: Grow Everything
Topics Covered:
enzymatic recycling, nylon 66 recycling, textile waste, circular economy, bioengineering, protein engineering, infinite recycling, sustainable fashion, Lululemon recycled jacket, plastic recycling technology
Have a question or comment? Message us here:
Text or Call (804) 505-5553
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Music by: Nihilore 
Production by: Amplafy Media