Y Combinator Startup Podcast

Waymo’s first autonomous demo took eighteen months. The product took fifteen years. Today, the Waymo Driver runs 500,000 trips a week — four million fully autonomous miles across fifteen cities, with 17 times fewer serious-injury crashes than human drivers.

At Startup School 2026, Waymo co-CEO Dmitri Dolgov shares the seven lessons behind that journey, from bridging the gap between a demo and a real product to building systems that can safely operate in the physical world.

Transcript: https://www.ycrootaccess.com/p/dmitri-dolgov-seven-lessons-from

In 2009, Patrick and John Collison went to Startup School in Berkeley, got sushi in Potrero Hill afterward, and decided on the walk home to start Stripe. The reasoning, as Patrick remembers it, was that “we might as well because it probably won't be that hard.”
It took two years to launch.
Seventeen years later, at Startup School 2026, he talks with YC's Harj Taggar about dropping out of MIT twice, why founders should ask what happens if they succeed, and what Stripe's own data says about the best time to start a company.

In 2001, Jeff Dean and Sanjay Ghemawat did the math and realized Google’s entire search index would fit in RAM — then shipped it in a few days, and search got fast. In 2013, another napkin calculation showed that three minutes of daily speech recognition per user would require doubling Google’s server fleet. That one became the TPU.

At Startup School 2026, Google’s Chief Scientist talks with YC’s Diana Hu through the thought experiments behind both, why inference hardware is the next specialization, and where two or three people in a room can still win.

Transcript: https://www.ycrootaccess.com/p/jeff-dean-the-1-rule-for-building

Alexandr Wang's advice to his 18-year-old self: develop your own internal compass for how the future will unfold, and hold conviction in it against the noise. At Startup School 2026, the Scale AI (YC S16) founder — now leading Meta's Superintelligence Labs — talks with Garry Tan about rebuilding a frontier lab from scratch, why talent density compounds, and how to spot the exponential worth betting your twenties on.

In 1969, we landed on the moon and flew Concorde. Half a century later, we could do neither.

Blake Scholl founded Boom Supersonic (YC W16), the startup building America’s first supersonic airliner, to change that. At Startup School 2026, he shares how a cardboard mockup with Office Depot seats became XB-1, the first independently developed jet to break the sound barrier, and why founders have to build for both the worst day and the best day.

He also answers founder questions about teaching yourself hard things, breaking into hardware without the right resume, and finding work-life harmony while building something ambitious.