Road to Resilience

Depression is often mistaken for ordinary sadness, but clinically it is something profoundly different: a medical illness that can alter the way the brain processes emotion, motivation, and even hope itself.
In this episode of Road to Resilience, host Stephen Calabria speaks with James Murrough, MD, PhD, to discuss how groundbreaking neuroimaging research explains why depression may leave the brain "entrapped" in inefficient patterns of activity, 
The conversation explores the difference between sadness and clinical depression, why chronic stress can reshape the brain, how behavioral therapy and medication help people break free from depression's grip, and why the brain's extraordinary capacity for change offers genuine reason for hope.
Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.
Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.

Resilience isn't just a personality trait—it's something the brain actively builds. 
In this episode of Road to Resilience, host Stephen Calabria speaks with Eric J. Nestler, MD, PhD, one of the world's foremost neuroscientists, about the remarkable capacity of the brain to adapt in the face of adversity.  
Drawing on decades of groundbreaking research into depression, addiction, and stress, Dr. Nestler explains why trauma doesn't affect everyone the same way, how resilience is shaped by both biology and experience, and what science is revealing about the brain's extraordinary ability to recover and change. 
The episode explores why supportive relationships matter, how chronic stress alters the brain, whether resilience can be cultivated at any age, and the everyday habits that can help strengthen our minds throughout life. 
Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.
Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.

When Jacqueline Mills noticed a new mole on her face, she trusted her instincts—even after her concerns were initially dismissed. Her persistence led to an early melanoma diagnosis and became a powerful reminder of how speaking up and seeking a second opinion can make all the difference.
In this episode of Road to Resilience, Jacqueline shares her story; she is followed by the Mount Sinai dermatologist who discovered her melanoma, Dr. Jesse Lewin, who expands the conversation to what everyone should know about skin health. 
Together, they discuss the warning signs of skin cancer, the ABCDEs of melanoma, smart sun protection, advances in early detection and imaging technology, and why the future of dermatologic care has never been brighter.
Whether you're heading to the beach or simply taking a closer look in the mirror, this conversation will leave you better equipped to protect your skin—and yourself.
Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.
Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.

Childhood trauma can leave lasting marks on the brain, body, and sense of safety—but it does not define a person’s future. 
In this episode of Road to Resilience, host Stephen Calabria speaks with Frank W. Putnam, MD, one of the country’s leading researchers on childhood trauma and maltreatment. Drawing on decades of clinical work and a landmark longitudinal study that followed abused girls from childhood into adulthood, Dr. Putnam explains how early maltreatment can shape mental health, physical health, development, and even biological aging. 
But the conversation is also about what helps people heal. Dr. Putnam discusses why safety is the foundation of recovery, how supportive relationships can change a child’s trajectory, and why resilience often begins with having options, stability, and someone who truly listens. 
Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.
Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.

Women's health is often associated with pregnancy and reproductive care—but that’s only part of the story.
In this episode of Road to Resilience, host Stephen Calabria sits down with two leaders at the forefront of a new era in women's healthcare: Dr. Joanne Stone, Chair of Obstetrics, Gynecology and Reproductive Science at Mount Sinai, and Dr. Anna Barbieri, gynecologist, menopause specialist, and clinical strategy leader for the Carolyn Rowan Center for Women’s Health and Wellness.
Together, they explore how women’s health is expanding beyond traditional boundaries to encompass cardiovascular health, mental health, aging, cancer prevention, hormonal health, and overall well-being across the lifespan. They discuss the longstanding disparities that have shaped research, diagnosis, and treatment for women, and how those gaps continue to affect patient care today.
Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.
Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.