Like any machine, bodies occasionally break down, and it's natural to go in search of a replacement part. Ancient societies featured simple prosthetics for teeth, noses, and limbs, while modern medicine pursues more advanced ways of replacing internal organs and microbiomes. But what is striking is not just the impressive ingenuity of our attempts to replicate human anatomy, but the surprising level of difficulty involved in doing it well. I talk with author Mary Roach about the many ways in which humans have chosen to replace bits of themselves, as told in her recent book Replaceable You: Adventures in Human Anatomy.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/15/328-mary-roach-on-replacing-parts-of-our-bodies/Support Mindscape on Patreon.Mary Roach received a bachelor's degree in psychology from Wesleyan University. Her books include multiple New York Times bestsellers and have appeared on numerous best-of lists. She was a guest editor in the Best American Science and Nature Writing series, and received the Rushdie Award from the Harvard Secular Society.Web siteWikipediaBlueskyGoodreads profileAmazon author pageSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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AMA | September 2025
Welcome to the September 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/09/08/ama-september-2025/Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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327 | Cass Sunstein on Liberalism
"Liberalism," divorced from its particular connotations in this or that modern political context, refers broadly to a philosophy of individual rights, liberties, and responsibilities, coupled with respect for institutions and rule of law over personalized power. As Cass Sunstein construes the term, liberalism encompasses a broad tent, from Ronald Reagan and Margaret Thatcher to Martin Luther King and Franklin Roosevelt. But liberalism is being challenged both from the right and from the left, by those who think that individual liberties can go too far. We talk about the philosophical case for liberalism as well as the challenges to it in modern politics, as discussed in his new book On Liberalism: In Defense of Freedom.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/01/327-cass-sunstein-on-liberalism/Support Mindscape on Patreon.Cass Sunstein received a J.D. from Harvard Law School, and worked as a clerk for Supreme Court Justice Thurgood Marshall. He is currently Robert Walmsley University Professor at Harvard. He served in several government roles during the Obama administration. He is recognized as "by far the most cited legal scholar in the United States and probably the world."Harvard web pageGoogle Scholar publicationsSubstackAmazon author pageWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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326 | Natalie Batalha on What We Know and Will Learn About Exoplanets
In a relatively short period of time, exoplanets (planets around stars other than our Sun) have gone from an intriguing conjecture to an active field of scientific study, with over 5,000 confirmed discoveries. The task now is to move beyond merely accumulating new examples, and embarking on systematic studies of their properties. What fraction of stars have planets, how are they distributed in size and distance, what kinds of atmospheres do they have, are any promising homes for life? I talk with Natalie Batalha about what we've learned so far, and prospects for future discoveries.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/08/25/326-natalie-batalha-on-what-we-know-and-will-learn-about-exoplanets/Support Mindscape on Patreon.Natalie Batalha received a Ph.D. in astrophysics from the University of California, Santa Cruz. She is currently a professor of astronomy and astrophysics at UCSC. She has served as Science Team Leader, Mission Scientist, and Project Scientist for NASA's Kepler satellite observatory. She is a member of the American Academy of Arts and Sciences, and was listed as one of Time Magazine's 100 Most Influential People in the World in 2017.Web pageGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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325 | Alvy Ray Smith on Pixar, Pixels, and the Great Digital Convergence
The world is becoming pixelated. As computers and other digital devices become ubiquitous, human knowledge and communication and information is gradually being converted into, and manipulated as, strings of bits. What does that really mean, and what are the ramifications going forward? Alvy Ray Smith is a computer scientist, co-founder of Pixar, and author of A Biography of the Pixel. We go through the journey of how he helped make computer animation a reality, and the implications of what he calls the "Great Digital Convergence."Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/08/18/325-alvy-ray-smith-on-pixar-pixels-and-the-great-digital-convergence/Support Mindscape on Patreon.Alvy Ray Smith received a Ph.D. in computer science from Stanford University. He has been a professor of electrical engineering and computer science at New York University, a member of the Computer Graphics Lab at the NY Institute of Technology, director of computer graphics at Lucasfilm, and cofounder of Pixar and Altamira. He is a member of the National Academy of Engineering and a Fellow of the America Association for the Advancement of Science as well as the American Society of Genealogists. He is the winner of two technical Academy Awards.Web siteGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Acerca de Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you’ve come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, philosophy, culture and much more.
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