Epigenetic coaching is a revolutionary approach to health and wellness that leverages the latest research on epigenetics to optimize gene expression. As you all know, epigenetics refers to changes in gene activity that are not caused by changes in the underlying DNA sequence, but rather by environmental factors such as diet, stress, and exercise. With the help of an epigenetic coach, like Lindsey Lekhraj, you can learn how to modify your lifestyle to positively influence gene expression, leading to improved health outcomes and a better quality of life. Who doesn’t want that?!Epigenetic coaching involves a personalized approach to wellness, taking into account your unique genetic makeup and environmental factors. By identifying specific genetic markers that are associated with different health outcomes, Lindsey is able to provide targeted recommendations for dietary and lifestyle changes that can optimize gene expression. These changes may include modifications to diet, exercise, stress management, and other factors, all with the goal of enhancing overall health and well-being. If you’re looking to take control of your health and wellness, you need to check out epigenetic coaching… now! Understanding how to regulate your genes through epigenetic coaching offers a cutting-edge approach that will lead to lasting results.In this week’s Everything Epigenetics podcast, I chat with Lindsey about how she became an epigenetic coach and her company, The Designer Genes Co. During our discussion, we also took a deep dive into my own genetic results, as I was actually lucky enough to go through Lindsey’s epigenetic coaching program myself. If you’re looking to upgrade your life, I highly recommend checking out her program and everything she has to offer… It really is a one-stop shop to improve your health. This is an incredibly useful conversion, so make sure to tune in!Lindsey is currently on a mission to help a million people understand their genetic makeup and to grow awareness of practitioner-grade genetic testing.In this episode of Everything Epigenetics, you’ll learn about: Lindsey’s unique journey and how she became involved in geneticsThe tools Lindsey discovered and uses to improve her overall healthHer company - The Designer Genes Co.Lindsey’s focus on bioindividuality The lack of education in women’s healthEpigenetic coachingThe perfect time to take a genetic testThe process of testing your genetic makeupHow our environment and upbringing influence our genesThe need for 1 on 1 interpretation when reviewing genetic results The perfect candidate for epigenetic coachingThe difference between practitioner grade genetic test and 23andMeMy COMT variant and what it means for my healthMy BDNF variant and what it means for my healthLindsey’s LYFE LabTesting and biomarkers included in LYFE LabChallenging your “truth”Lindsey’s coaching program for those wanting to create a model just like hersWhere to find Lindsey:Website: thedesignergenesco.comInstagram: instagram.com/thedesignergenescoThank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

I hate to break it to you, but yes - what your grandmother did directly influences how your DNA is regulated today. This is called epigenetic transgenerational inheritance. Epigenetic transgenerational inheritance refers to the transmission of epigenetic marks from one generation to the next. This phenomenon can occur through the germline and affect the development and health of future generations.To further explain, it is possible for environmental factors that affected our grandmother to influence our epigenetics through epigenetic transgenerational inheritance. For example, if our grandmother was exposed to a toxin that caused changes in her epigenetic marks, those changes could be passed down to subsequent generations. This could lead to an increased risk of disease or other health conditions in her grandchildren, even if they were not directly exposed to the toxin themselves.Additionally, lifestyle choices such as diet and exercise habits can also have epigenetic effects that can be inherited. If your grandmother had a poor diet or was sedentary, for example, this could have altered her epigenetic marks and potentially contributed to a higher risk of obesity or other metabolic disorders in her grandchildren.In this week’s Everything Epigenetics podcast, Dr. Michael Skinner speaks with me about just that - epigenetic transgenerational inheritance, a term he coined in 2005. We discuss how Dr. Skinner and his team have shown that exposure to certain environmental factors, such as chemicals, nutrition, and stress, can cause changes in the epigenome that can be passed down through multiple generations. Dr. Skinner and I also chat about the mechanisms underlying this transgenerational epigenetic inheritance and the implications for human health and disease, including developmental disorders, obesity, and reproductive problems.In this episode of Everything Epigenetics, you’ll learn about: Dr. Michael Skinner’s history and how he became interested in things that cannot be explained by classical geneticsThe history of Epigenetics starting with Conrad Waddington who coined the term “Epigenetics” in 1942Epigenetic mechanism and marks (DNA methylation, histone modifications, chromatin structure, non-coding RNA, RNA methylation, and DNA adenine)How Dr. Skinner discovered epigenetic transgenerational inheritance Epigenetic transgenerational inheritance The role of the germ cell in this type of inheritance The limitations of genetic data in determining phenotypic outcomes Classical examples of epigenetic transgenerational inheritanceGenerational toxicology The work Dr. Skinner is performing now (F10 generations in rats) Environmental toxicants that have been shown to be associated with the transgenerational inheritance of increased disease susceptibilityHow different toxins can have an affect on our health today How other epidemiological factors can promote a transgenerational effect How Dr. Skinner’s work has changed his own lifestyle Using epigenetic biomarkers for preventative therapeutic strategies to detect disease early The limitations of government policies regulating toxicant exposure The best way to move forward using epigenetics in the healthcare industryDr. Skinner’s most recent work (which had over 500+ million reaches) looking at epigenetics in twins with different workout regimens How epigenetics can predict preeclampsia, preterm birth, male infertility, and moreThe lack of funding in this area of science Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

Cancer acts as an accelerator of aging. Furthermore, we know that cancer and cancer therapies can elicit aging-associated cognitive phenotypes and reveal or exacerbate underlying cognitive deficits, increase the risk of physical impairment, heart disease, diabetes and other chronic health conditions, and accelerate the hallmarks of aging. Dr. Christin Burd and her team, from The Ohio State University, have been asking key questions about just that… age-acceleration in cancer. To understand this further, they have been researching cancer therapies, T cells, senescence, and p16 and how they are related to epigenetic aging. T cells, senescence, and p16 are all known to play important roles in cancer development and progression. T cells are key players in the immune system's response to cancer, while senescence is a process that limits the proliferation of damaged cells and is implicated in aging and cancer. P16 is a tumor suppressor gene that is often mutated in cancer cells. By studying the relationship between epigenetic clocks and these key factors, we hope to gain a better understanding of how cancer cells develop and progress, as well as how they may be treated. Aging biomarkers, including epigenetic clocks, may provide important answers to some of the most pressing questions in cancer research today.In this week’s Everything Epigenetics podcast, Dr. Christin Burd speaks with me about the importance of biomarkers and epigenetic clocks for older adults with cancer, as epigenetic clocks are currently not trained on cancer populations. We also discuss the development of a new ‘p16INK4a epi-clock’ (that I am most excited about) which may allow for the measurement of different aspects of aging using the same platform. Being an educator at The Ohio State University, Dr. Burd is passionate about diversity, equity, and inclusion (DEI) initiatives in science. Dr. Burd continues to focus her research on identifying mechanisms to prevent melanoma and improve clinical outcomes in older adults with cancer.In this episode of Everything Epigenetics, you’ll learn about: - How Dr. Burd became interested in cancer and what led her to the career she has today- Aging as a risk factor for cancer - What cancer therapies are causing aging and how that process can be mitigated - The collaboration between TruDiagnostic and Dr. Burd’s team- Ohio State’s CARE Clinic- The main mission of Dr. Burd’s ;lab - Why we need biomarkers for older adults with cancer- Using T cells to measure Epigenetic Age- How T cell Epigenetic Age relates to clinical measures of faulty, cognitive decline, and toxicity risk- Details of the cohort Dr. Burd is investigating- How cancer therapies are related to Epigenetic Age- How cancer patients Epigenetic Age relates to outcomes - Senescence markers and how they are involved in Dr. Burd’s work- The pros and cons of senescent cells- How to measure senescent cells- If T cell p16INK4a levels and Epigenetic Age are equivalent measures - How p16 levels are currently measured- How to get involved in the field of science - Dr. Burd’s advice on navigating the transition from highschool to college- The grant application process and why there is a lack of understanding hereWhere to find Dr. Christin Burd:Dr. Burd’s profile at The Ohio State University - https://u.osu.edu/burd-25/Twitter  - https://twitter.com/christinburdThank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

Maintaining muscle mass is crucial for healthy aging, as it is closely linked to overall physical function and quality of life. As we age, our bodies naturally experience a decline in muscle mass and strength, known as sarcopenia. This loss of muscle mass can lead to a range of negative health outcomes, including decreased mobility, increased risk of falls and fractures, and decreased metabolic rate. Additionally, loss of muscle mass can contribute to chronic conditions such as obesity, diabetes, and cardiovascular disease. By developing an epigenetic clock for skeletal muscle, Dr. Voisin and her colleagues have identified specific methylation patterns that are associated with muscle aging. This research not only sheds light on the biological mechanisms behind sarcopenia, but may also provide new targets for interventions aimed at preserving muscle mass and function in older adults.In this week’s Everything Epigenetics podcast, Dr. Sarah Voisin and I focus on her 2020 paper which describes her development of a human muscle-specific epigenetic clock that predicts age with better accuracy than the pan-tissue clock. Yes - you heard that right… better accuracy than Dr. Steve Horvath’s 2013 clock. Dr. Voisin and I also chat about the importance of skeletal muscle and how this relates to epigenetics and aging, the power of machine learning, and how identifying which methylation positions change as we age may give us insight into the underlying reason as to WHY we age rather than just HOW. She is now focused on creating an atas of epigenetics for all human tissues at the cellular level by combining 75,000 DNA methylation profiles across 18 tissues. In this episode of Everything Epigenetics, you’ll learn about: How Dr. Voisin got her start in statistics and biology The importance of skeletal muscle tissue and how this relates to Epigenetics and AgingWhen to start exercising and moving your bodyThe importance of weight lifting How often we should be moving our body Why Dr. Voisin decided to develop this type of Epigenetic ClockThe limitations of the Horvath 2013 Clock as it relates to skeletal muscle The complications of data miningThe importance of collaboration and data sharing  How Dr. Voisin created her muscle-specific Epigenetic Clock The power of machine learningHow the muscle clock outperforms Dr. Steve Horvath’s 2013 pan-tissue ClockDr. Voisin’s epigenetic wide association studies (EWAS) she performedDifferentiated methylated positions (DMPs) in this studyDifferentiated methylation regions (DMRs) in this studyThe utility/application of the skeletal muscle Epigenetic ClockDr. Voisin’s next big project (I’m so excited about her next project!!!) MEAT (muscle epigenetic age test)Where to find Dr. Voisin:Email: [email protected] Twitter: https://www.vu.edu.au/research/sarah-voisinGitHub account:https://github.com/sarah-voisinThank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.

It’s always a pleasure speaking with Dr. Habib, and in this podcast he doesn’t disappoint. His mantra of “The right treatment, for the right patient, at the right time” has revolutionized the way healthcare providers should approach clinical care. He takes an integrated approach to healthcare, and notes that Next Health is not “married” to a single treatment method or restricted by conventional medical training. His practice incorporates a wide array of techniques and methodologies to get to the root cause of disease. In addition, he uses the best tools in the healing arts to provide precision diagnosis, primarily drug-free treatment, and treatment success that far exceeds traditional medicine. In this episode of the Everything Epigenetics podcast, Dr. Habib speaks with me about the details of integrating Epigenetic Methylation testing in his medical practice and how it changes his point of care when addressing aging, and why it’s critical that more healthcare providers transition from the current state of our health system (sick-care) towards a model which focuses on functional and preventative medicine. In this podcast you’ll hear:- Dr. Habib’s approach to functional medicine using Epigenetic Testing- The journey of a functional medicine patient - A discussion of how to be in charge of your own health- The importance of trust between you and your healthcare provider- The science behind growth being great (while you’re young) and the benefits of temporary stress as it relates to accelerated aging- How glucose and blood flow plays a major role in the aging process- About the need for healthcare providers to move from a disease/sick-care model towards a preventive, regenerative approachThank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how.